Evidence map›Paper›PMID 32414823›Full record

ArticleBMJ open2020

Trends in oral anticoagulant prescribing in individuals with type 2 diabetes mellitus: a population-based study in the UK.

Hassan Alwafi, Li Wei, Abdallah Y Naser, Pajaree Mongkhon, Gary Tse, Kenneth K C Man, J Simon Bell, Jenni Ilomaki, Gang Fang, Ian C K Wong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. The safety and efficacy of the use of oral anticoagulant medications in patients with diabetes mellitus: A systematic review.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021
    Review
  6. Article
  7. Observational
  8. Synergistic Anti-inflammatory and Neuroprotective Effects ofFrontiers in cell and developmental biology · 2021
    Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 6 countries.

Hassan AlwafiResearch Department of Practice and Policy, School of Pharmacy, University College London, London, London, UK.ORCID 0000-0001-5627-1633
Li WeiResearch Department of Practice and Policy, School of Pharmacy, University College London, London, London, UK.
Abdallah Y NaserFaculty of Pharmacy, Isra University, Amman, Jordan.
Pajaree MongkhonDivision of Pharmacy Practice, Department of Pharmaceutical Care, School of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand.
Gary TseDepartment of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong Kong, New Territories, Hong Kong.
Kenneth K C ManResearch Department of Practice and Policy, School of Pharmacy, University College London, London, London, UK.ORCID 0000-0001-8645-1942
J Simon BellCentre for Medicine Use and Safety, Monash University, Melbourne, Victoria, Australia.
Jenni IlomakiCentre for Medicine Use and Safety, Monash University, Melbourne, Victoria, Australia.
Gang FangDivision of Pharmaceutical Outcomes and Policy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Ian C K WongResearch Department of Practice and Policy, School of Pharmacy, University College London, London, London, UK wongick@hku.hk.
University College London · GBMonash University · AUChinese University of Hong Kong · HKIsra University · JOUniversity of North Carolina at Chapel Hill · USUniversity of Phayao · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate oral anticoagulant (OAC) prescribing trends in type 2 diabetes mellitus (T2DM) in the UK from 2001 to 2015.

designA cross-sectional drug utilisation study.

settingElectronic health records from The Health Improvement Network primary care database in the UK.

participantsIndividuals with T2DM who received a record of OAC prescription. OUTCOME MEASURES: The prescribing trends of OAC medications in individuals with T2DM were examined from 2001 to 2015, stratified by age, gender and therapeutic classifications.

resultsA total of 361 635 individuals with T2DM were identified, of whom 36 570 were prescribed OAC from 2001 to 2015. The prevalence of OAC prescribing increased by 50.0%, from 1781 individuals receiving OAC prescriptions (IROACP) (4.4 (95% CI 4.2 to 4.6) per 100 persons) in 2001, to 17 070 IROACP (6.6 (95% CI 6.5 to 6.7) per 100 persons) in 2015. The prevalence of warfarin prescribing decreased by 14.0%, from 1761 individuals receiving warfarin prescriptions (IRWP) (98.9 (95% CI 98.4 to 99.4) per 100 persons) in 2001, to 14 533 IRWP (85.1 (95% CI 84.6 to 85.7) per 100 persons) in 2015. This corresponded with increased prescribing of direct oral anticoagulants (DOACs), from 18 individuals receiving DOAC prescriptions (IRDOACP) (0.1 (95% CI 0.08 to 0.23) per 100 persons) in 2010, to 3016 IRDOACP (17.6 (95% CI 17.1 to 18.2) per 100 persons) in 2015, during the same period.

conclusionsPrescribing of OACs in individuals with T2DM increased from 2001 to 2015. Since the introduction of DOACs, there has been a clear shift in prescribing towards these agents. Future studies are needed to assess the safety of coadministration of OAC medications and antidiabetic therapy with T2DM.

Indexed as

Atrial FibrillationDiabetes Mellitus, Type 2Administration, OralAgedAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsAnticoagulantsCross-Sectional StudiesFemaleHumansMaleUnited KingdomAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsAnticoagulantsanticoagulationdiabetes & endocrinologyepidemiology

Identifiers

PMID32414823
PMCPMC7232627
OpenAlexW3024500389

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.