Evidence map›Paper›PMID 32414522›Full record

ArticleThe American journal of emergency medicine2020

Weakness and elevated creatinine kinase as the initial presentation of coronavirus disease 2019 (COVID-19).

Kok Hoe Chan, Iyad Farouji, Amany Abu Hanoud, Jihad Slim

Abstract readCase Reports
In one paragraph

Article in The American journal of emergency medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Kok Hoe ChanDepartment of Medical Education, Saint Michael's Medical Centre, New York Medical College, NJ, United States. Electronic address: kchan2@primehealthcare.com.
Iyad FaroujiDepartment of Medical Education, Saint Michael's Medical Centre, New York Medical College, NJ, United States.
Amany Abu HanoudDepartment of Infectious Disease, Saint Michael's Medical Centre, New York Medical College, NJ, United States.
Jihad SlimDepartment of Medical Education, Saint Michael's Medical Centre, New York Medical College, NJ, United States; Department of Infectious Disease, Saint Michael's Medical Centre, New York Medical College, NJ, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 is a global public health emergency with more than one million positive cases across the globe. COVID-19 has a multifaceted presentation. We are herein to report two cases of SARS-CoV-2 induced rhabdomyolysis with an initial presentation of weakness and elevated creatinine kinase (CK). Both patients had no respiratory symptoms, they only complained of generalized weakness and were found to have elevated CK. Routine chest X-ray showed bilateral infiltrates in both cases and subsequently reverse-transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2 was positive. To the best of our knowledge, there was only one literature to date documented SARS-CoV-2 induced rhabdomyolysis as a late complication of COVID-19 patient. Our cases showed that elevated CK and rhabdomyolysis can be the sole initial presentation of patients with COVID-19 and total CK should be ordered in every patient on admission.

Indexed as

AgedBetacoronavirusCoronavirus InfectionsCOVID-19CreatinineFemaleHumansMalePandemicsPneumonia, ViralRadiography, ThoracicRhabdomyolysisSARS-CoV-2Tomography, X-Ray ComputedCreatinineCOVID-19Elevated creatinine kinaseRhabdomyolysisSARS-CoV-2

Identifiers

PMID32414522
PMCPMC7211689

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.