ArticleBiological psychiatry2020
What Is the Link Between Attention-Deficit/Hyperactivity Disorder and Sleep Disturbance? A Multimodal Examination of Longitudinal Relationships and Brain Structure Using Large-Scale Population-Based Cohorts.
Article in Biological psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Sleep disorders and structural alterations in brain regions linked with motivation: a neuroimaging meta-analysis.Scientific reports · 2026Pooled it
- Sleep dysregulation in ADHD children: a systematic review and meta-analysis.Psychological medicine · 2025Pooled it
- Improving health through research: The ABCD StudyDevelopmental cognitive neuroscience · 2026Article
- Exploring the Relationship Between Age of Nap Cessation, Screen-Positive Autism Spectrum Disorder Traits and Diagnosis of Attention-Deficit Hyperactivity Disorder.Journal of autism and developmental disorders · 2026Article
- The Relationship Between ADHD Symptom Severity and Sleep Disturbance Using Accelerometer and the Subjective Sleep Disturbance Scale.Journal of attention disorders · 2026Article
- The Adolescent Brain Cognitive Development (ABCD) Study: Ten years of statistical and methodological contributions.Developmental cognitive neuroscience · 2026Article
- Dynamic relationship and pleiotropic loci of attention deficit hyperactivity disorder with sleep traits.Translational psychiatry · 2026Article
- Article
- What we have learned about adolescent mental health and where we are going after a decade with the Adolescent Brain Cognitive Development Study.Developmental cognitive neuroscience · 2026Review
- Clinical significance of ADHD traits in central disorders of hypersomnolence.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Striatum volume and affective symptomatology are associated with sleep in schizophrenia.Journal of psychiatric research · 2026Article
- Sleep disturbances in children and adolescents with attention-deficit/hyperactivity disorder: A narrative review.World journal of clinical pediatrics · 2025Review
- Hypothalamic volume is associated with dysregulated sleep in autistic and non-autistic young children.Autism : the international journal of research and practice · 2025Article
- Multimodal Neuroimaging Signature of Sleep Problems Predicts Preadolescent Mental Health Trajectories.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Parental psychopathology, family conflict, brain function, and child autistic-like traits in early adolescents.Psychological medicine · 2025Article
- Topical review: sleep regulation as a novel target for treating preschool-aged children with attention-deficit/hyperactivity disorder symptoms.Journal of pediatric psychology · 2025Review
- Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia.Translational psychiatry · 2025Article
- Longitudinal and cross-sectional predictors of sleep disturbance in a treatment follow-up sample with Tourette's disorder.Frontiers in psychiatry · 2025Article
- Sleep and psychiatric disorders: Bidirectional interactions and shared neurobiological mechanisms.PLOS mental health · 2025Review
Corrections and comments
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Authors and funding
16 authors at 9 institutions in 4 countries.
Funding
Abstract
backgroundAttention-deficit/hyperactivity disorder (ADHD) comorbid with sleep disturbances can produce profound disruption in daily life and negatively impact quality of life of both the child and the family. However, the temporal relationship between ADHD and sleep impairment is unclear, as are underlying common brain mechanisms.
methodsThis study used data from the Quebec Longitudinal Study of Child Development (n = 1601, 52% female) and the Adolescent Brain Cognitive Development Study (n = 3515, 48% female). Longitudinal relationships between symptoms were examined using cross-lagged panel models. Gray matter volume neural correlates were identified using linear regression. The transcriptomic signature of the identified brain-ADHD-sleep relationship was characterized by gene enrichment analysis. Confounding factors, such as stimulant drugs for ADHD and socioeconomic status, were controlled for.
resultsADHD symptoms contributed to sleep disturbances at one or more subsequent time points in both cohorts. Lower gray matter volumes in the middle frontal gyrus and inferior frontal gyrus, amygdala, striatum, and insula were associated with both ADHD symptoms and sleep disturbances. ADHD symptoms significantly mediated the link between these structural brain abnormalities and sleep dysregulation, and genes were differentially expressed in the implicated brain regions, including those involved in neurotransmission and circadian entrainment.
conclusionsThis study indicates that ADHD symptoms and sleep disturbances have common neural correlates, including structural changes of the ventral attention system and frontostriatal circuitry. Leveraging data from large datasets, these results offer new mechanistic insights into this clinically important relationship between ADHD and sleep impairment, with potential implications for neurobiological models and future therapeutic directions.
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