ArticleJournal of foot and ankle research2020
Phenotypes and outcomes in middle-aged patients with diabetic foot ulcers: a retrospective cohort study.
Article in Journal of foot and ankle research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Incidence and risk factors for amputation in Chinese patients with diabetic foot ulcers: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- [A prospective randomized controlled study of antibiotic bone cement in the treatment of diabetic foot ulcer].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Trial
- Translational development of ABCB5Stem cell research & therapy · 2022Trial
- Economic burden of extremities amputations: A 10-year retrospective analysis of direct surgical and hospitalization costs.Medicine · 2026Article
- Mortality predictors and survival nomogram for hospitalized diabetic foot patients: a decade-long cohort.Frontiers in endocrinology · 2026Article
- Predictors of Unfavorable Outcomes in Diabetic Foot Ulcers.Diagnostics (Basel, Switzerland) · 2025Article
- Risk factors for diabetic foot ulcer in diabetic patients at the Tehran diabetes clinic: a case-control study.Journal of diabetes and metabolic disorders · 2025Article
- Machine learning-based risk prediction model for neuropathic foot ulcers in patients with diabetic peripheral neuropathy.Journal of diabetes investigation · 2025Article
- Analysis of risk factors for foot ulcers in diabetes patients with neurovascular complications.BMC public health · 2025Article
- Trends and Inequalities in Diabetes-Related Complications Among U.S. Adults, 2000-2020.Diabetes care · 2025Article
- Associations between different insulin resistance indices and the risk of all-cause mortality in peritoneal dialysis patients.Lipids in health and disease · 2024Article
- Prognostic factors for delayed healing of complex wounds in adults: A scoping review.International wound journal · 2023Article
- Etiology, Epidemiology, and Disparities in the Burden of Diabetic Foot Ulcers.Diabetes care · 2023Review
- The association of chronic, enhanced immunosuppression with outcomes of diabetic foot infections.Endocrinology, diabetes & metabolism · 2022Article
- Topical Application of Chinese Formula Yeliangen Promotes Wound Healing in Streptozotocin-Induced Diabetic Rats.Journal of diabetes research · 2022Article
- Machine Learning Models for Predicting the Risk of Hard-to-Heal Diabetic Foot Ulcers in a Chinese Population.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlthough ageing could increase the risk of delayed healing in diabetic foot ulcers (DFUs) patients, data from middle-aged patients remains greatly limited. The purpose of this study was to explore the clinical phenotypes, outcomes and predictive factors of DFU in middle-aged patients.
methodsA retrospective cohort study conducted with 422 consecutive inpatients with DFUs who visited our hospital between May 2010 and September 2017; participants were recruited and assigned according to age to either the middle-aged group or the elderly group. The Demographics, ulcer characteristics, comorbidities and diabetes complications, laboratory tests, socioeconomic data and final outcomes were collected. Moreover, predictive factors of adverse outcomes in middle-aged DFUs patients were assessed.
resultsMiddle-aged patients were more likely to have worse lifestyle and glucose control, were more likely to have microangiopathy as a complication, and tended to have larger and deeper ulcers; however, these patients also had higher rates of healing and lower rates of mortality and major amputaion than elderly patients. Severe infection,living alone,current smoking cigarettes, and having a high white blood cell count were independent risk factors for adverse outcomes in middle-aged patients.
conclusionsDFUs are relatively common in middle-aged patients with diabetes, and these patients have unique clinical phenotypes and risk profiles. Nonetheless, further investigation is needed to clarify whether intervention targeting these easily recognizable risk factors can improve healing and survival rates in middle-aged DFU patients.
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