ArticleBMC neurology2020
Dynamic cerebral autoregulation is an independent outcome predictor of acute ischemic stroke after endovascular therapy.
Article in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06361017 (Research of the Prediction of Hemorrhage Transformation and Clinical Outcome by Cerebral Autoregulation After Endovascular Thrombectomy in Acute Ischemic Stroke Patients Caused by Middle Cerebral Artery or Internal Carotid Artery Occlusion.), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Research of the Prediction of Hemorrhage Transformation and Clinical Outcome by Cerebral Autoregulation After Endovascular Thrombectomy in Acute Ischemic Stroke Patients Caused by Middle Cerebral Artery or Internal Carotid Artery Occlusion.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Pooled it
- Impact of Cerebral Autoregulation Monitoring in Cerebrovascular Disease: A Systematic Review.Neurocritical care · 2022Pooled it
- Bilateral dynamic cerebral autoregulation assessment during endovascular treatment in large-vessel occlusion stroke.Experimental physiology · 2026Article
- Cerebral small vessel disease impairs dynamic cerebral autoregulation and mediates outcomes after stroke thrombectomy.Therapeutic advances in neurological disorders · 2026Article
- Dynamic cerebral autoregulation during and 3 months after endovascular treatment in large vessel occlusion stroke.Scientific reports · 2025Observational
- Characteristics of Cerebral Autoregulation After Mechanical Thrombectomy and Its Relationship With Prognosis.CNS neuroscience & therapeutics · 2025Article
- Association of hemodynamic variability during endovascular stroke treatment with functional outcome and parenchymal hemorrhage.Therapeutic advances in neurological disorders · 2025Article
- Individualized autoregulation-guided arterial blood pressure management in neurocritical care.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- In-depth hemodynamic assessment in acute mild stroke patients with large vessel occlusion or stenosis.BMC neurology · 2024Article
- The impact of collateral therapeutics on stroke hemodynamics in normotensive and hypertensive rats: a step toward translation.Frontiers in neurology · 2024Article
- Dynamic cerebral autoregulation measured by diffuse correlation spectroscopy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- A systematic review on the assessment of cerebral autoregulation in patients with Large Vessel Occlusion.Frontiers in neurology · 2023Review
- Review
- Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Review
- The consistency of invasive and non-invasive arterial blood pressure for the assessment of dynamic cerebral autoregulation in NICU patients.Frontiers in neurology · 2022Article
- Cerebral Autoregulation in Ischemic Stroke: From Pathophysiology to Clinical Concepts.Brain sciences · 2021Review
- Dynamic trajectory of cerebral autoregulation recovery after carotid artery stenting in severe carotid stenosis.Frontiers in neurologyArticle
- Article
- Quantifying cerebral autoregulation following endovascular thrombectomy using wavelet transformation.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndovascular therapy (EVT) is increasingly used to improve cerebral reperfusion after moderate-to-severe acute ischemic stroke (AIS). However, the influence of hemodynamic factors on clinical outcome is still unclear after EVT. Dynamic cerebral autoregulation (dCA) is an important brain reserve mechanism and is impaired after AIS. This study aimed to explore the role of dCA in predicting the outcome of AIS patients after EVT.
methodsAIS patients with severe stenosis/occlusion of unilateral middle cerebral artery (MCA) or internal carotid and treatment with EVT were enrolled to receive dCA examinations at the 24 h, 72 h and 7th day after stroke onset. Healthy volunteers were also recruited as controls. DCA was recorded from spontaneous fluctuations of blood pressure and MCA flow velocity. Transfer function analysis was used to derive dCA parameters, including phase difference (PD) and coherence in the low-frequency range (0.06-0.12 Hz). The clinical outcome was measured using the modified Rankin Scale (mRS) at 90 days after onset. Multivariate logistic regression was performed to reveal the correlation between dCA and clinical outcomes. The receiver operation characteristics (ROC) curve was performed to determine the cut-off point of PD.
resultsA total of 62 AIS patients and 77 healthy controls were included. Compared with controls, dCA were impaired bilaterally till to 7th day after onset in patients, presenting as much lower PD value on the ipsilateral side. During follow-up, we found that PD on the ipsilateral side at 24 h after onset was significantly lower in patients with unfavourable outcome (n = 41) than those with favourable outcome (n = 21), even after adjustment of confounding factors (p = 0.009). ROC curve analysis revealed that PD < 26.93° was an independent predictor of unfavourable-outcome.
conclusionIn AIS patients after EVT, dCA was impaired on both sides over the first 7 days. PD on the ipsilateral side at 24 h after onset is an independent unfavourable-outcome predictor for AIS after EVT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.