Evidence map›Paper›PMID 32414346›Full record

ArticleBMC public health2020

Adherence to ready-to-use food and acceptability of outpatient nutritional therapy in HIV-infected undernourished Senegalese adolescents: research-based recommendations for routine care.

Fatou Niasse, Marie Varloteaux, Karim Diop, Sidy Mokhtar Ndiaye, François Niokhor Diouf, Pape Birane Mbodj, Babacar Niang, Aminata Diack, Cecile Cames

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMC public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03101852 (Effectiveness and Acceptability of Nutritional Rehabilitation Based on Ready-to-use Food in HIV-infected Children and Adolescents in Senegal), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03101852 nacompletednot on this map

Effectiveness and Acceptability of Nutritional Rehabilitation Based on Ready-to-use Food in HIV-infected Children and Adolescents in Senegal: The Multicentre SNAC'S Study

TypeinterventionalSponsorInstitut de Recherche pour le DeveloppementRan2015 to 2017Enrolled185ConditionsMalnutrition, HIV/AIDSArmsPlumpy Nut, Plumpy Sup
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 5 countries.

Fatou NiasseComité national de lutte contre le sida (CNLS), Dakar, Sénégal.
Marie VarloteauxInstitut de recherche pour le développement (IRD), UMI233 TransVIHmi, INSERM U1175, Université de Montpellier, 911 Av Agropolis, 34394, Montpellier, France.
Karim DiopCentre régional de recherche et de formation à la prise en charge clinique (CRCF), Dakar, Sénégal.
Sidy Mokhtar NdiayeCentre régional de recherche et de formation à la prise en charge clinique (CRCF), Dakar, Sénégal.
François Niokhor DioufCentre hospitalier régional, Ziguinchor, Sénégal.
Pape Birane MbodjCentre hospitalier régional, Kaolack, Sénégal.
Babacar NiangCentre Hospitalier National Universitaire d'Enfants Albert Royer, Dakar, Sénégal.
Aminata DiackCentre Hospitalier National Universitaire d'Enfants Albert Royer, Dakar, Sénégal.
Cecile CamesInstitut de recherche pour le développement (IRD), UMI233 TransVIHmi, INSERM U1175, Université de Montpellier, 911 Av Agropolis, 34394, Montpellier, France. cecile.cames@ird.fr.ORCID http://orcid.org/0000-0001-8374-7107
Centre Hospitalier National Universitaire de Fann · SNComité National de Lutte contre le SIDA · CMInserm · FRInstitut de Recherche pour le Développement · BJMinistère de la Santé Publique et Action Sociale · SNZiguinchor University · SN

Funding

Agence Nationale de Recherches sur le Sida et les Hépatites Virales NoneExpertise France Initiative 5pc of the global Fund 14INI203Sidaction AI25-2-02405
6 · The paper itself

Abstract

backgroundReady-to-use food (RUF) is increasingly used for nutritional therapy in HIV-infected individuals. However, practical guidance advising nutrition care to HIV-infected adolescents is lacking, so that little is known about the acceptability of such therapy in this vulnerable population. This study assesses the overall acceptability and perception of a RUF-based therapy and risk factors associated with sub-optimal RUF intake in HIV-infected undernourished adolescents in Senegal.

methodsParticipants 5 to 18 years of age with acute malnutrition were enrolled in 12 HIV clinics in Senegal. Participants were provided with imported RUF, according to WHO prescription weight- and age-bands (2009), until recovery or for a maximum of 9-12 months. Malnutrition and recovery were defined according to WHO growth standards. Adherence was assessed fortnightly by self-reported RUF intake over the period. Sub-optimal RUF intake was defined as when consumption of the RUF provision was < 50%. RUF therapy acceptability and perceptions were assessed using a structured questionnaire at week 2 and focus group discussions (FGDs) at the end of the study. Factors associated with sub-optimal RUF intake at week 2 were identified using a stepwise logistic regression model.

resultsWe enrolled 173 participants, with a median age of 12.5 years (Interquartile range: 9.5-14.9), of whom 61% recovered from malnutrition within the study period. Median follow-up duration was 66 days (21-224). RUF consumption was stable, varying between 64 and 57% of the RUF provided, throughout the follow-up. At week 2, sub-optimal RUF intake was observed in 31% of participants. Dislike of the taste of RUF (aOR = 5.0, 95% CI: 2.0-12.3), HIV non-disclosure (5.1, 1.9-13.9) and food insecurity (2.8, 1.1-7.2) were the major risk factors associated with sub-optimal RUF intake at week 2. FGDs showed that the need to hide from others to avoid sharing and undesirable effects were other constraints on RUF feeding.

conclusionsThis study revealed several factors reducing the acceptability and adherence to RUF therapy based on WHO guidelines in HIV-infected adolescents. Tailoring prescription guidance and empowering young patients in their care are crucial levers for improving the acceptability of RUF-based therapy in routine care.

trial registrationClinicalTrials.gov identifier: NCT03101852, 04/04/2017.

Indexed as

OutpatientsAdolescentAdultBody WeightChildChild, PreschoolFemaleFood SupplyHIV InfectionsHumansMaleMalnutritionSenegalVulnerable PopulationsAcceptabilityAcute malnutritionAdherenceAdolescentsAfricaChildrenHIVReady-to-use food

Identifiers

PMID32414346
PMCPMC7227087
OpenAlexW3028201637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.