Evidence map›Paper›PMID 32414213›Full record

ArticleCancers2020

Novel Gene Fusions in Glioblastoma Tumor Tissue and Matched Patient Plasma.

Lan Wang, Anudeep Yekula, Koushik Muralidharan, Julia L Small, Zachary S Rosh, Keiko M Kang, Bob S Carter, Leonora Balaj

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  4. Article
  5. Article
  6. Article
  7. Liquid biopsy: early and accurate diagnosis of brain tumor.Journal of cancer research and clinical oncology · 2022
    Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lan WangDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.
Anudeep YekulaDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.
Koushik MuralidharanDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.
Julia L SmallDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-7135-6299
Zachary S RoshDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.
Keiko M KangDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.
Bob S CarterDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.
Leonora BalajDepartment of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA.
Harvard University · US

Funding

The role of microvesicles in giloma virotherapyP01CA069246 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAREST, ALAIN · 1996 to 2021
$30.9M
Liquid Biopsy for treatment stratification of IDH1.R132H and EGFRvIII mutant gliomasU01CA230697 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CARTER, BOB S, SKOG, JOHAN · 2018 to 2022
$4.0M
Imaging and Liquid Biopsy for Glioma Diagnosis and Treatment MonitoringR01CA239078 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BALAJ, LEONORA, LEE, HAKHO · 2020 to 2024
$3.1M
NCI NIH HHS CA069246NCI NIH HHS CA230697NCI NIH HHS CA239078NCI NIH HHS P01 CA069246NCI NIH HHS R01 CA239078NCI NIH HHS U01 CA230697
6 · The paper itself

Abstract

Sequencing studies have provided novel insights into the heterogeneous molecular landscape of glioblastoma (GBM), unveiling a subset of patients with gene fusions. Tissue biopsy is highly invasive, limited by sampling frequency and incompletely representative of intra-tumor heterogeneity. Extracellular vesicle-based liquid biopsy provides a minimally invasive alternative to diagnose and monitor tumor-specific molecular aberrations in patient biofluids. Here, we used targeted RNA sequencing to screen GBM tissue and the matched plasma of patients (

Indexed as

extracellular vesiclesgene fusionsglioblastomaliquid biopsyRNA-seq

Identifiers

PMID32414213
PMCPMC7281415
OpenAlexW3024955311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.