Evidence map›Paper›PMID 32414175›Full record

ArticleMaterials (Basel, Switzerland)2020

RGD-Dendrimer-Poly(L-lactic) Acid Nanopatterned Substrates for the Early Chondrogenesis of Human Mesenchymal Stromal Cells Derived from Osteoarthritic and Healthy Donors.

Cristina Rodríguez-Pereira, Anna Lagunas, Ignasi Casanellas, Yolanda Vida, Ezequiel Pérez-Inestrosa, José A Andrades, José Becerra, Josep Samitier, Francisco J Blanco, Joana Magalhães

Open access · goldAbstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Cristina Rodríguez-PereiraUnidad de Medicina Regenerativa. Grupo de Investigación en Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complejo Hospitalario Universitario de A Coruña (CHUAC), Sergas, 15006 A Coruña, Spain.
Anna LagunasNetworking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain.ORCID 0000-0002-0936-3401
Ignasi CasanellasNetworking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain.ORCID 0000-0002-5264-169X
Yolanda VidaDpto. Química Orgánica, Universidad de Málaga-IBIMA, Campus de Teatinos s/n, 29071 Málaga, Spain.ORCID 0000-0002-7004-4629
Ezequiel Pérez-InestrosaDpto. Química Orgánica, Universidad de Málaga-IBIMA, Campus de Teatinos s/n, 29071 Málaga, Spain.ORCID 0000-0001-7546-5273
José A AndradesNetworking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain.
José BecerraNetworking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain.
Josep SamitierNetworking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain.
Francisco J BlancoUnidad de Medicina Regenerativa. Grupo de Investigación en Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complejo Hospitalario Universitario de A Coruña (CHUAC), Sergas, 15006 A Coruña, Spain.ORCID 0000-0001-9821-7635
Joana MagalhãesUnidad de Medicina Regenerativa. Grupo de Investigación en Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complejo Hospitalario Universitario de A Coruña (CHUAC), Sergas, 15006 A Coruña, Spain.ORCID 0000-0002-1395-2209
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine · ESUniversidade da Coruña · ESAndalusian Centre for Nanomedicine and Biotechnology · ES

Funding

AdvanceCat with the support of ACCIÓ 17 (Catalonia Trade and Investment; Generalitat de Catalunya) Catalonian ERDF operational program 2014-2020.Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina CIBER-BBN Intramural Projects Program (CHONDRONANONET). CIBER-BBN is a national initiative of ISCIII.CERCA Programme and by the Commission for Universities and Research of the Department of Innovation, Universities, and Enterprise of the Generalitat de Catalunya 2017 SGR 1079European Commission INTERREG V cooperation program for Spain-Portugal (POCTEP) 2014-2020 project (0245_IBEROS_1_E)Instituto de Salud Carlos III i-PFIS doctoral Program (IFI15/00151)Junta de Andalucía UMA18-FEDERJA-007Ministerio de Economía, Industria y Competitividad, Gobierno de España CTQ2016-75870-PMinisterio de Economía, Industria y Competitividad, Gobierno de España Subsidies for Predoctoral Contracts for the Training of Doctors open call, co-funded by the European Social Fund (2016)
6 · The paper itself

Abstract

Aiming to address a stable chondrogenesis derived from mesenchymal stromal cells (MSCs) to be applied in cartilage repair strategies at the onset of osteoarthritis (OA), we analyzed the effect of arginine-glycine-aspartate (RGD) density on cell condensation that occurs during the initial phase of chondrogenesis. For this, we seeded MSC-derived from OA and healthy (H) donors in RGD-dendrimer-poly(L-lactic) acid (PLLA) nanopatterned substrates (RGD concentrations of 4 × 10

Indexed as

cell condensationchondrogenic differentiationgap junctionsosteoarthritisRGD-density

Identifiers

PMID32414175
PMCPMC7287591
OpenAlexW3025695630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.