Evidence map›Paper›PMID 32414170›Full record

ArticleCells2020

Characterization of Plasma-Derived Small Extracellular Vesicles Indicates Ongoing Endothelial and Platelet Activation in Patients with Thrombotic Antiphospholipid Syndrome.

Ula Štok, Elizabeta Blokar, Metka Lenassi, Marija Holcar, Mojca Frank-Bertoncelj, Andreja Erman, Nataša Resnik, Snežna Sodin-Šemrl, Saša Čučnik, Katja Perdan Pirkmajer and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Platelets and Thrombotic Antiphospholipid Syndrome.Journal of clinical medicine · 2024
    Review
  10. Article
  11. Platelet-Derived Microparticles and Autoimmune Diseases.International journal of molecular sciences · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Biomedicines · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ula ŠtokDepartment of Rheumatology, University Medical Centre Ljubljana, SI-1000 Ljubljana, Slovenia.ORCID 0000-0002-4842-916X
Elizabeta BlokarDepartment of Rheumatology, University Medical Centre Ljubljana, SI-1000 Ljubljana, Slovenia.
Metka LenassiInstitute of Biochemistry, Faculty of Medicine, University of Ljubljana, SI-1000 Ljubljana, Slovenia.ORCID 0000-0002-9488-6855
Marija HolcarInstitute of Biochemistry, Faculty of Medicine, University of Ljubljana, SI-1000 Ljubljana, Slovenia.
Mojca Frank-BertonceljCentre of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, 8952 Schlieren, Switzerland.
Andreja ErmanInstitute of Cell Biology, Faculty of Medicine, University of Ljubljana, SI-1000 Ljubljana, Slovenia.
Nataša ResnikInstitute of Cell Biology, Faculty of Medicine, University of Ljubljana, SI-1000 Ljubljana, Slovenia.
Snežna Sodin-ŠemrlDepartment of Rheumatology, University Medical Centre Ljubljana, SI-1000 Ljubljana, Slovenia.
Saša ČučnikDepartment of Rheumatology, University Medical Centre Ljubljana, SI-1000 Ljubljana, Slovenia.
Katja Perdan PirkmajerDepartment of Rheumatology, University Medical Centre Ljubljana, SI-1000 Ljubljana, Slovenia.
Aleš AmbrožičDepartment of Rheumatology, University Medical Centre Ljubljana, SI-1000 Ljubljana, Slovenia.
Polona ŽigonDepartment of Rheumatology, University Medical Centre Ljubljana, SI-1000 Ljubljana, Slovenia.ORCID 0000-0001-6637-9744
University of Ljubljana · SIUniversity of Primorska · SILjubljana University Medical Centre · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antiphospholipid syndrome (APS) is a systemic autoimmune disease, characterized by thrombosis, obstetric complications and the presence of antiphospholipid antibodies (aPL), which drive endothelial injury and thrombophilia. Extracellular vesicles (EVs) have been implicated in endothelial and thrombotic pathologies. Here, we characterized the quantity, cellular origin and the surface expression of biologically active molecules in small EVs (sEVs) isolated from the plasma of thrombotic APS patients (

Indexed as

Platelet ActivationAdultAgedAntiphospholipid SyndromeBiomarkersBlood DonorsBlood ProteinsCell Adhesion MoleculesCell CommunicationCell MembraneExtracellular VesiclesFemaleHumansMaleMiddle AgedThrombosisBiomarkersBlood ProteinsCell Adhesion Moleculesadhesion moleculesantiphospholipid syndromeendothelial activationplatelet activationsmall extracellular vesiclessurface protein markersthrombosis

Identifiers

PMID32414170
PMCPMC7290474
OpenAlexW3025557783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.