Evidence map›Paper›PMID 32414139›Full record

ArticleAntioxidants (Basel, Switzerland)2020

Zinc Concentration Dynamics Indicate Neurological Impairment Odds after Traumatic Spinal Cord Injury.

Raban Arved Heller, André Sperl, Julian Seelig, Patrick Haubruck, Tobias Bock, Theresa Werner, Albert Besseling, Qian Sun, Lutz Schomburg, Arash Moghaddam and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Raban Arved HellerInstitute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, corporate member of FreieUniversität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health; 13353 Berlin, Germany.
André SperlHeidelberg Trauma Research Group, Department of Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, 68118 Heidelberg, Germany.
Julian SeeligInstitute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, corporate member of FreieUniversität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health; 13353 Berlin, Germany.
Patrick HaubruckHeidelberg Trauma Research Group, Department of Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, 68118 Heidelberg, Germany.
Tobias BockHeidelberg Trauma Research Group, Department of Trauma and Reconstructive Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, 68118 Heidelberg, Germany.
Theresa WernerBG Trauma Centre Ludwigshafen, Department of Physiotherapy, 67071 Ludwigshafen, Germany.
Albert BesselingBG Trauma Centre Ludwigshafen, Department of Physiotherapy, 67071 Ludwigshafen, Germany.
Qian SunInstitute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, corporate member of FreieUniversität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health; 13353 Berlin, Germany.
Lutz SchomburgInstitute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, corporate member of FreieUniversität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health; 13353 Berlin, Germany.
Arash MoghaddamAschaffenburg Trauma and Orthopedic Research Group, Center for Orthopedics, Trauma Surgery and Sports Medicine, Hospital Aschaffenburg-Alzenau, 63739 Aschaffenburg, Germany.
Bahram BiglariBG Trauma Centre Ludwigshafen, Department of Paraplegiology, 67071 Ludwigshafen, Germany.
Heidelberg University · DEHumboldt-Universität zu Berlin · DEKlinikum Ludwigshafen · DEKlinikum Aschaffenburg · DEThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic Spinal Cord Injury (TSCI) is debilitating and often results in a loss of motor and sensory function caused by an interwoven set of pathological processes. Oxidative stress and inflammatory processes are amongst the critical factors in the secondary injury phase after TSCI. The essential trace element Zinc (Zn) plays a crucial role during this phase as part of the antioxidant defense system. The study aims to determine dynamic patterns in serum Zn concentration in patients with TSCI and test for a correlation with neurological impairment. A total of 42 patients with TSCI were enrolled in this clinical observational study. Serum samples were collected at five different points in time after injury (at admission, and after 4 h, 9 h, 12 h, 24 h, and 3 d). The analysis of the serum Zn concentrations was conducted by total reflection X-ray fluorescence (TXRF). The patients were divided into two groups-a study group S (

Indexed as

neuroprotectionneurotraumaregenerationtraumatic spinal cord injuryzinc

Identifiers

PMID32414139
PMCPMC7278606
OpenAlexW3024754235

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.