Evidence map›Paper›PMID 32414131›Full record

ReviewJournal of clinical medicine2020

CD56bright Natural Killer Cells: A Possible Biomarker of Different Treatments in Multiple Sclerosis.

Alice Laroni, Antonio Uccelli

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Natural Killer Cells: Dual Regulators and Therapeutic Targets in Multiple Sclerosis Immunopathogenesis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
    Review
  2. CD56Clinical & translational immunology · 2026
    Article
  3. Article
  4. Article
  5. Natural killer cells in multiple sclerosis: foe or friends?Frontiers in cellular neuroscience · 2025
    Review
  6. Article
  7. Article
  8. Regulatory NK cells in autoimmune disease.Iranian journal of basic medical sciences · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Circulating CCR6Clinical & translational immunology · 2022
    Article
  14. Article
  15. The phenotype of CD3-CD56Reumatologia · 2022
    Article
  16. Review
  17. Observational
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alice LaroniDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health and Center of Excellence for Biomedical Research, University of Genova, 16132 Genova, Italy.ORCID 0000-0001-5599-9788
Antonio UccelliDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health and Center of Excellence for Biomedical Research, University of Genova, 16132 Genova, Italy.ORCID 0000-0002-2008-6038

Funding

Fondazione Italiana Sclerosi Multipla 271/1/14Fondazione Italiana Sclerosi Multipla 297/09/F14IRCCS Ospedale Policlinico San Martino Ricerca Corrente 2019Ministero della Salute GR-2016-02361163Ministero dell'Istruzione, dell'Università e della Ricerca 2017K55HLCUniversità degli Studi di Genova Fondi di ricerca di Ateneo
6 · The paper itself

Abstract

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system, which leads, in many cases, to irreversible disability. More than 15 disease-modifying treatments (DMTs) are available for the treatment of MS. Clinical activity or activity at magnetic resonance imaging (MRI) are now used to assess the efficacy of DMTs, but are negative prognostic factors per se. Therefore, a biomarker permitting us to identify patients who respond to treatment before they develop clinical/radiological signs of MS activity would be of high importance. The number of circulating CD56

Indexed as

biomarkerCD56bright NK cellsdisease-modifying treatmentsinnate immunitymultiple sclerosisnatural killer cellsNK regulatory cells

Identifiers

PMID32414131
PMCPMC7291063

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.