Evidence map›Paper›PMID 32414114›Full record

ReviewInternational journal of molecular sciences2020

Bioresorbable Polymeric Scaffold in Cardiovascular Applications.

Daniel Wee Yee Toong, Han Wei Toh, Jaryl Chen Koon Ng, Philip En Hou Wong, Hwa Liang Leo, Subramanian Venkatraman, Lay Poh Tan, Hui Ying Ang, Yingying Huang

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.

  1. Pooled it
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  15. Research progress of absorbable stents.International journal of medical sciences · 2024
    Review
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  20. Novel Self-expanding Shape-Memory Bioresorbable Peripheral Stent Displays Efficient Delivery, Accelerated Resorption, and Low Luminal Loss in a Porcine Model.Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Daniel Wee Yee ToongSchool of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, Singapore 639798, Singapore.
Han Wei TohNational Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, Singapore.
Jaryl Chen Koon NgNational Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, Singapore.
Philip En Hou WongNational Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, Singapore.
Hwa Liang LeoDepartment of Biomedical Engineering, 4 Engineering Drive 3, Singapore 117583, Singapore.
Subramanian VenkatramanMaterials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117575, Singapore.
Lay Poh TanSchool of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, Singapore 639798, Singapore.
Hui Ying AngNational Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, Singapore.
Yingying HuangSchool of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, Singapore 639798, Singapore.
National University of Singapore · SGNanyang Technological University · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advances in material science and innovative medical technologies have allowed the development of less invasive interventional procedures for deploying implant devices, including scaffolds for cardiac tissue engineering. Biodegradable materials (e.g., resorbable polymers) are employed in devices that are only needed for a transient period. In the case of coronary stents, the device is only required for 6-8 months before positive remodelling takes place. Hence, biodegradable polymeric stents have been considered to promote this positive remodelling and eliminate the issue of permanent caging of the vessel. In tissue engineering, the role of the scaffold is to support favourable cell-scaffold interaction to stimulate formation of functional tissue. The ideal outcome is for the cells to produce their own extracellular matrix over time and eventually replace the implanted scaffold or tissue engineered construct. Synthetic biodegradable polymers are the favoured candidates as scaffolds, because their degradation rates can be manipulated over a broad time scale, and they may be functionalised easily. This review presents an overview of coronary heart disease, the limitations of current interventions and how biomaterials can be used to potentially circumvent these shortcomings in bioresorbable stents, vascular grafts and cardiac patches. The material specifications, type of polymers used, current progress and future challenges for each application will be discussed in this manuscript.

Indexed as

Absorbable ImplantsBiocompatible MaterialsBlood Vessel ProsthesisCardiovascular SystemHumansPolymersStentsTissue EngineeringBiocompatible MaterialsPolymersbiomaterialsbioresorbable scaffoldscardiac patchescardiovascular tissue engineeringpolymeric scaffoldsvascular grafts

Identifiers

PMID32414114
PMCPMC7279389
OpenAlexW3024795555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.