Evidence map›Paper›PMID 32414111›Full record

ArticleCells2020

P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b.

Randa Naffa, Lisa Vogel, Luca Hegedűs, Katalin Pászty, Sarolta Tóth, Kornélia Kelemen, Neha Singh, Attila Reményi, Enikő Kállay, Mihály Cserepes and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. The Essential Oil fromPharmaceuticals (Basel, Switzerland) · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Metastasis and MAPK Pathways.International journal of molecular sciences · 2022
    Review
  11. Article
  12. Review
  13. The Role of Calcium Signaling in Melanoma.International journal of molecular sciences · 2022
    Review
  14. Article
  15. Review
  16. Review
  17. The Plasma Membrane CaCancers · 2021
    Article
  18. Article
  19. Nicardipine Inhibits Breast Cancer MigrationFrontiers in pharmacology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Randa Naffa2nd Institute of Pathology, Semmelweis University, H-1091 Budapest, Hungary.ORCID 0000-0001-5192-1799
Lisa VogelInstitute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna A-1090, Austria.
Luca HegedűsDepartment of Thoracic Surgery, Ruhrlandklinik, University Clinic, D-45239 Essen, Germany.
Katalin PásztyDepartment of Biophysics and Radiation Biology, Semmelweis University, H-1094 Budapest, Hungary.
Sarolta TóthDepartment of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, H-1117 Budapest, Hungary.
Kornélia Kelemen2nd Institute of Pathology, Semmelweis University, H-1091 Budapest, Hungary.
Neha SinghInstitute of Organic Chemistry, Research Centre for Natural Sciences, HAS, H-1117 Budapest, Hungary.ORCID 0000-0001-8650-4960
Attila ReményiInstitute of Organic Chemistry, Research Centre for Natural Sciences, HAS, H-1117 Budapest, Hungary.
Enikő KállayInstitute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna A-1090, Austria.ORCID 0000-0002-4996-0104
Mihály CserepesNational Institute of Oncology, Department of Experimental Pharmacology, H-1122 Budapest, Hungary.ORCID 0000-0003-4816-2618
József TóváriNational Institute of Oncology, Department of Experimental Pharmacology, H-1122 Budapest, Hungary.
Michael GruschInstitute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna A-1090, Austria.ORCID 0000-0001-5486-9340
Ágnes Enyedi2nd Institute of Pathology, Semmelweis University, H-1091 Budapest, Hungary.ORCID 0000-0002-7366-9376
Semmelweis University · HUMedical University of Vienna · ATInstitute of Organic Chemistry · HUNational Institute of Oncology · HUEötvös Loránd University · HURuhrlandklinik · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastatic melanoma is the most aggressive type of skin cancer. Previously, we identified the plasma membrane Ca

Indexed as

ProteolysisCalciumCell Cycle CheckpointsCell DeathCell Line, TumorCell MembraneCell MovementCell ProliferationEndocytosisEndosomesHumansJNK Mitogen-Activated Protein KinasesLysosomesMelanomaMutationNeoplasm MetastasisATP2B4 protein, humanCalciumJNK Mitogen-Activated Protein KinasesNF-kappa Bp38 Mitogen-Activated Protein KinasesPlasma Membrane Calcium-Transporting ATPasesProtein Kinase InhibitorsProto-Oncogene Proteins B-rafBRAF mutant melanomacalcium signalingendocytosismetastasisp38 mitogen-activated protein kinase (MAPK)plasma membrane Ca2+ATPase isoform 4b

Identifiers

PMID32414111
PMCPMC7290426
OpenAlexW3025131477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.