Evidence map›Paper›PMID 32414058›Full record

ArticleMolecules (Basel, Switzerland)2020

Modulating the Properties of Fe(III) Macrocyclic MRI Contrast Agents by Appending Sulfonate or Hydroxyl Groups.

Didar Asik, Rachel Smolinski, Samira M Abozeid, Travis B Mitchell, Steven G Turowski, Joseph A Spernyak, Janet R Morrow

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Fe(III)Inorganic chemistry · 2023
    Article
  10. Article
  11. An Fe complex forChemical science · 2023
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Enzyme Control Over Ferric Iron Magnetostructural Properties.Angewandte Chemie (International ed. in English) · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Didar AsikDepartment of Chemistry, University at Buffalo, The State University of New York, Amherst, NY 14260, USA.
Rachel SmolinskiDepartment of Chemistry, University at Buffalo, The State University of New York, Amherst, NY 14260, USA.
Samira M AbozeidDepartment of Chemistry, University at Buffalo, The State University of New York, Amherst, NY 14260, USA.
Travis B MitchellDepartment of Chemistry, University at Buffalo, The State University of New York, Amherst, NY 14260, USA.ORCID 0000-0002-6844-1596
Steven G TurowskiDepartment of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, NY 14263, USA.
Joseph A SpernyakDepartment of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, NY 14263, USA.ORCID 0000-0002-5049-4737
Janet R MorrowDepartment of Chemistry, University at Buffalo, The State University of New York, Amherst, NY 14260, USA.ORCID 0000-0003-4160-7688
University at Buffalo, State University of New York · USRoswell Park Comprehensive Cancer Center · US

Funding

Iron based T1 MRI contrast agents as alternatives to gadolinium agentsR03EB025369 · NIBIB · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MORROW, JANET RUTH, SPERNYAK, JOSEPH ANDREW · 2017 to 2018
$177k
National Science Foundation STTR-1746556NIBIB NIH HHS R03 EB025369NIH HHS 1R03EB02536901
6 · The paper itself

Abstract

Complexes of Fe(III) that contain a triazacyclononane (TACN) macrocycle, two pendant hydroxyl groups, and a third ancillary pendant show promise as MRI contrast agents. The ancillary group plays an important role in tuning the solution relaxivity of the Fe(III) complex and leads to large changes in MRI contrast enhancement in mice. Two new Fe(III) complexes, one with a third coordinating hydroxypropyl pendant, Fe(L2), and one with an anionic non-coordinating sulfonate group, Fe(L1)(OH

Indexed as

Contrast MediaFerric CompoundsMacrocyclic CompoundsMagnetic Resonance ImagingAnimalsMiceMice, Inbred BALB CContrast MediaFerric CompoundsMacrocyclic CompoundsFe(III) complexesin vivokidney imagemacrocyclic ligandsMRIpharmacokineticsrelaxivitysulfonate groupT1 contrast agentsTACN

Identifiers

PMID32414058
PMCPMC7288058
OpenAlexW3025655500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.