Evidence map›Paper›PMID 32414011›Full record

ReviewGenes2020

Transcriptomic and Proteostasis Networks of CFTR and the Development of Small Molecule Modulators for the Treatment of Cystic Fibrosis Lung Disease.

Matthew D Strub, Paul B McCray

Abstract readReview
In one paragraph

Review in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Restoring chloride efflux in cystic fibrosis with TMEM16a antisense oligonucleotides.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. New Therapies to Correct the Cystic Fibrosis Basic Defect.International journal of molecular sciences · 2021
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Matthew D StrubInterdisciplinary Graduate Program in Genetics, The University of Iowa, Iowa City, IA 52242, USA.
Paul B McCrayInterdisciplinary Graduate Program in Genetics, The University of Iowa, Iowa City, IA 52242, USA.

Funding

Respiratory virus infection in early cystic fibrosis lung diseaseP01HL091842 · NHLBI · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2008 to 2022
$34.2M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008629 · NIGMS · UNIVERSITY OF IOWA · PI EBERL, DANIEL F · 1997 to 2021
$4.1M
Mining a microRNA Regulated Gene Network to Rescue CFTR-DeltaF508 FunctionR01HL118000 · NHLBI · UNIVERSITY OF IOWA · PI MCCRAY, PAUL B · 2014 to 2017
$1.9M
NIDDK NIH HHS P30 DK054759NIGMS NIH HHS T32 GM008629NIH HHS DK54759NIH HHS P01 HL091842NIH HHS P01 HL51670NIH HHS R01 HL118000NIH HHS T32GM008629NIH HHS UG3 HL-147366
6 · The paper itself

Abstract

Cystic fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the CF transmembrane conductance regulator (

Indexed as

Drug DiscoveryMutationProteostasisTranscriptomeBinding SitesClinical Trials as TopicCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEndoplasmic Reticulum StressHigh-Throughput Screening AssaysHumansIon Channel GatingModels, MolecularMolecular ChaperonesProtein ConformationProtein DomainsCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorMolecular ChaperonesRNA, MessengerRNA, UntranslatedUbiquitin-Protein LigasesCFTRcystic fibrosisdrug developmentproteostasissmall moleculestranscriptomics

Identifiers

PMID32414011
PMCPMC7288469

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.