Evidence map›Paper›PMID 32413634›Full record

ArticleJournal of inorganic biochemistry2020

New in vitro highly cytotoxic platinum and palladium cyanoximates with minimal side effects in vivo.

Stephanie D Dannen, Lauren Cornelison, Paul Durham, John E Morley, Kiana Shahverdi, Junwei Du, Haiying Zhou, Leland C Sudlow, Daniel Hunter, Matthew D Wood and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inorganic biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Stephanie D DannenDepartment of Chemistry, Temple Hall 431, Missouri State University, 901 S. National, Springfield, MO 65897, USA.
Lauren CornelisonDepartment of Biology, Missouri State University, MC/Center for Biomedical & Life Sciences, Springfield, MO 65897, USA.
Paul DurhamDepartment of Biology, Missouri State University, MC/Center for Biomedical & Life Sciences, Springfield, MO 65897, USA.
John E MorleyDivision of Geriatric Medicine, Saint Louis University, St. Louis, MO 63110, USA.
Kiana ShahverdiDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Junwei DuInstitute of Materials Science and Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
Haiying ZhouDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Leland C SudlowDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Daniel HunterDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Matthew D WoodDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Mikhail Y BerezinDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Institute of Materials Science and Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA. Electronic address: berezinm@wustl.edu.
Nikolay GerasimchukDepartment of Chemistry, Temple Hall 431, Missouri State University, 901 S. National, Springfield, MO 65897, USA. Electronic address: NNGerasimchuk@MissouriState.edu.
Washington University in St. Louis · USMissouri State University · USSaint Louis University · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
AN IMAGING-BASED APPROACH TO UNDERSTAND AND PREDICT CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHYR01CA208623 · NCI · WASHINGTON UNIVERSITY · PI BEREZIN, MIKHAIL Y. · 2017 to 2021
$2.2M
NCATS NIH HHS UL1 TR002345NCI NIH HHS R01 CA208623
6 · The paper itself

Abstract

Several biologically active bivalent Pd and Pt complexes with two structurally similar cyanoxime ligands abbreviated as H(DECO): 2-oximino-2-cyano-N,N'-diethylacetamide, and H(PyrCO): 2-oximino-2-cyan-N-pyrrolidine acetamide were synthesized and characterized using spectroscopic methods, thermal analysis and X-ray crystallography. Structures revealed planar cis-geometry of studied complexes. Freshly obtained Pt(DECO)

Indexed as

Coordination ComplexesCytotoxinsPalladiumPlatinumAnimalsDrug Screening Assays, AntitumorHeLa CellsHumansMaleMiceNeoplasmsCoordination ComplexesCytotoxinsPalladiumPlatinumAnimal modelCrystal structuresHuman cancer cellsin vitro studiesin vivo studiesPd/Pt-cyanoximates

Identifiers

PMID32413634
PMCPMC7518941
OpenAlexW3022331502

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.