Trial reportBehaviour research and therapy2020
Double trouble: Do symptom severity and duration interact to predicting treatment outcomes in adolescent depression?
Trial report in Behaviour research and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Comparing apples and oranges in youth depression treatments? A quantitative critique of the evidence base and guidelines.BMJ mental health · 2025Pooled it
- Life events and treatment prognosis for depression: A systematic review and individual patient data meta-analysis.Journal of affective disorders · 2022Pooled it
- The contribution of depressive 'disorder characteristics' to determinations of prognosis for adults with depression: an individual patient data meta-analysis.Psychological medicine · 2021Pooled it
- The importance of transdiagnostic symptom level assessment to understanding prognosis for depressed adults: analysis of data from six randomised control trials.BMC medicine · 2021Trial
- Development of a baseline battery to optimize depression treatment assignment in primary care: Balancing breadth and brevity.Journal of affective disorders · 2026Article
- Health and social care use, costs, and satisfaction among key workers accessing Resilience Hub support during the COVID-19 pandemic.BMC health services research · 2025Article
- Measuring Alliance and Symptom Severity in Psychotherapy Transcripts Using Bert Topic Modeling.Administration and policy in mental health · 2024Article
- Methods for quantifying the heterogeneity of psychopathology.BMC psychiatry · 2023Article
- Trajectories of depression and anxiety symptom severity during psychological therapy for common mental health problems.Psychological medicine · 2023Article
- Why is it so hard to identify (consistent) predictors of treatment outcome in psychotherapy? - clinical and research perspectives.BMC psychology · 2023Review
- Circadian rhythm biomarker from wearable device data is related to concurrent antidepressant treatment response.NPJ digital medicine · 2023Article
- Symptom-specific effects of counselling for depression compared to cognitive-behavioural therapy.BMJ mental health · 2023Article
- Predicting prognosis for adults with depression using individual symptom data: a comparison of modelling approaches.Psychological medicine · 2023Article
- Ketamine-assisted psychotherapy in adolescents with multiple psychiatric diagnoses.Frontiers in psychiatry · 2023Article
- The protective role of father behaviour in the relationship between maternal postnatal depression and child mental health.JCPP advances · 2022Article
- Correlates and Predictors of Chronicity among Adolescents Living in Puerto Rico With a History of Depressive Symptoms.Revista Puertorriquena de psicologiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Studies suggest that depression severity and duration interact to predict outcomes in depression treatment. To our knowledge, no study has explored this question in a sample with a placebo control, two therapies, and their combination nor with adolescents. We used data from the Treatment of Adolescent Depression Study (N = 439), in which adolescent were randomized to placebo (PBO), cognitive-behavioral therapy (CBT), antidepressants medications (MEDs), or their combination (COMB). We explore the interaction between depression severity, chronicity, and treatments (vs. placebo) in predicting outcomes. There was interaction between severity and chronicity when comparing COMB and CBT with PBO, but not MEDs. In non-chronic depression, the effects of CBT were inversely related to severity to the point that CBT appeared iatrogenic with more severe depression. In chronic depression, the effects of CBT did not vary by severity, but the relative effects of COMB grew, being smallest in milder, more dysthymic-like depression, and largest in chronic-severe depression. These findings support calls to classify depression by severity and chronicity as well efforts to risk stratify patients to different intensity of care according to these variables.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.