Evidence map›Paper›PMID 32413324›Full record

ReviewTrends in biochemical sciences2020

Art and Science of the Cellular Mesoscale.

David S Goodsell, Arthur J Olson, Stefano Forli

Abstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. The application of metaverse in mental health.Frontiers in public health · 2025
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. The structured organization ofProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Article
  10. Building Structural Models of a Whole Mycoplasma Cell.Journal of molecular biology · 2022
    Article
  11. Article
  12. Visualizing Presynaptic Active Zones and Synaptic Vesicles.Frontiers in synaptic neuroscience · 2022
    Article
  13. Review
  14. Article
  15. Article
  16. Modeling in the Time of COVID-19: Statistical and Rule-based Mesoscale Models.IEEE transactions on visualization and computer graphics · 2021
    Article
  17. Article
  18. Article
  19. Seeing the PDB.The Journal of biological chemistry
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David S GoodsellDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Research Collaboratory for Structural Bioinformatics Protein Data Bank, Rutgers, the State University of New Jersey, Piscataway, NJ 08854, USA. Electronic address: goodsell@scripps.edu.
Arthur J OlsonDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Stefano ForliDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Funding

Project 9P50GM103368 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SHARPLESS, KARL BARRY · 2012 to 2016
$20.0M
PDB MANAGEMENT BY THE RESEARCH COLLABORATORY FOR STRUCTURAL BIOINFORMATICSR01GM133198 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI BURLEY, STEPHEN K · 2019 to 2023
$19.3M
AutoDock Suite: Next Generation Environment for Drug DesignR01GM069832 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI FORLI, STEFANO · 2004 to 2025
$10.9M
Modeling and Interacting with the Visible Molecular CellR01GM120604 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI AUTIN, LUDOVIC · 2016 to 2025
$4.2M
NIGMS NIH HHS P50 GM103368NIGMS NIH HHS R01 GM069832NIGMS NIH HHS R01 GM120604NIGMS NIH HHS R01 GM133198
6 · The paper itself

Abstract

Experimental information from microscopy, structural biology, and bioinformatics may be integrated to build structural models of entire cells with molecular detail. This integrative modeling is challenging in several ways: the intrinsic complexity of biology results in models with many closely packed and heterogeneous components; the wealth of available experimental data is scattered among multiple resources and must be gathered, reconciled, and curated; and computational infrastructure is only now gaining the capability of modeling and visualizing systems of this complexity. We present recent efforts to address these challenges, both with artistic approaches to depicting the cellular mesoscale, and development and application of methods to build quantitative models.

Indexed as

Cell BiologyComputational BiologyDrug DiscoveryMolecular Structurecell functioncell structuredrug designdrug discoveryintegrative structural biologymesoscale modelingmolecular functionmolecular structure

Identifiers

PMID32413324
PMCPMC7230070

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.