ArticleCurrent biology : CB2020
Basal Forebrain Parvalbumin Neurons Mediate Arousals from Sleep Induced by Hypercarbia or Auditory Stimuli.
Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 51 citations in OpenAlex.
- Effects of high-definition transcranial direct current stimulation for the treatment of chronic insomnia: a randomized, double-blind, controlled trial.Scientific reports · 2025Trial
- Sleep period noise induces wakefulness via the paraventricular thalamic lateral septum circuit in mice.iScience · 2026Article
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- The Geometry of Layer 2/3 Cortical Sound Processing in Slow Wave Sleep.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening.Science advances · 2025Article
- Calcitonin Gene-Related Peptide (CGRP)-Expressing Neurons in the External Lateral Parabrachial Area Regulate Pain-Induced Sleep Disturbances.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A role for the thalamus in danger evoked awakening during sleep.Nature communications · 2025Article
- Identifying the Brain Circuits that Regulate Pain-Induced Sleep Disturbances.bioRxiv : the preprint server for biology · 2024Article
- A distributed auditory network mediated by pontine central gray underlies ultra-fast awakening in response to alerting sounds.Current biology : CB · 2024Article
- Parvalbumin-expressing basal forebrain neurons mediate learning from negative experience.Nature communications · 2024Article
- Lateral parabrachial FoxP2 neurons regulate respiratory responses to hypercapnia.Nature communications · 2024Article
- Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in the basal forebrain.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Basal forebrain parvalbumin neurons modulate vigilant attention and rescue deficits produced by sleep deprivation.Journal of sleep research · 2024Article
- Article
- A midbrain GABAergic circuit constrains wakefulness in a mouse model of stress.Nature communications · 2024Article
- Cardio-audio synchronization elicits neural and cardiac surprise responses in human wakefulness and sleep.Communications biology · 2024Article
- Dexmedetomidine modulates neuronal activity of horizontal limbs of diagonal band via α2 adrenergic receptor in mice.BMC anesthesiology · 2023Article
- Activation of Basal Forebrain Astrocytes Induces Wakefulness without Compensatory Changes in Sleep Drive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- N-acetylcysteine treatment mitigates loss of cortical parvalbumin-positive interneuron and perineuronal net integrity resulting from persistent oxidative stress in a rat TBI model.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
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15 authors at 5 institutions in 1 country.
Funding
Abstract
The ability to rapidly arouse from sleep is important for survival. However, increased arousals in patients with sleep apnea and other disorders prevent restful sleep and contribute to cognitive, metabolic, and physiologic dysfunction [1, 2]. Little is currently known about which neural systems mediate these brief arousals, hindering the development of treatments that restore normal sleep. The basal forebrain (BF) receives inputs from many nuclei of the ascending arousal system, including the brainstem parabrachial neurons, which promote arousal in response to elevated blood carbon dioxide levels, as seen in sleep apnea [3]. Optical inhibition of the terminals of parabrachial neurons in the BF impairs cortical arousals to hypercarbia [4], but which BF cell types mediate cortical arousals in response to hypercarbia or other sensory stimuli is unknown. Here, we tested the role of BF parvalbumin (PV) neurons in arousal using optogenetic techniques in mice. Optical stimulation of BF-PV neurons produced rapid transitions to wakefulness from non-rapid eye movement (NREM) sleep but did not affect REM-wakefulness transitions. Unlike previous studies of BF glutamatergic and cholinergic neurons, arousals induced by stimulation of BF-PV neurons were brief and only slightly increased total wake time, reminiscent of clinical findings in sleep apnea [5, 6]. Bilateral optical inhibition of BF-PV neurons increased the latency to arousal produced by exposure to hypercarbia or auditory stimuli. Thus, BF-PV neurons are an important component of the brain circuitry that generates brief arousals from sleep in response to stimuli, which may indicate physiological dysfunction or danger to the organism.
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