Evidence map›Paper›PMID 32413198›Full record

ArticleAngewandte Chemie (International ed. in English)2020

Pillar[n]MaxQ: A New High Affinity Host Family for Sequestration in Water.

Weijian Xue, Peter Y Zavalij, Lyle Isaacs

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Article
  3. Synthesis and Applications of Sulfur-Containing Macrocycles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Reversible Photoswitching of Donor-Acceptor Stenhouse Adducts in Water.Journal of the American Chemical Society · 2026
    Article
  9. Article
  10. Article
  11. A Synthetic Lectin for Glucuronate.ACS central science · 2025
    Article
  12. Article
  13. Article
  14. Partially Sulfated Pillar[5]Arenes: Synthesis and Molecular Recognition Properties.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  15. Assembly-enhanced recognition: A biomimetic pathway to achieve ultrahigh affinities.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Weijian XueDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.
Peter Y ZavalijDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.ORCID 0000-0001-5762-3469
Lyle IsaacsDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.ORCID 0000-0002-4079-332X

Funding

Helium Recovery System for University of MarylandR01GM132345 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI ISAACS, LYLE D · 2019 to 2022
$1.9M
NIGMS NIH HHS R01 GM132345
6 · The paper itself

Abstract

We report the synthesis, X-ray crystal structure, and molecular recognition properties of pillar[n]arene derivative P[6]AS, which we refer to as Pillar[6]MaxQ along with analogues P[5]AS and P[7]AS toward guests 1-18. The ultratight binding affinity of P[5]AS and P[6]AS toward quaternary (di)ammonium ions renders them prime candidates for in vitro and in vivo non-covalent bioconjugation, for imaging and delivery applications, and as in vivo sequestration agents.

Indexed as

Macrocyclic CompoundsQuaternary Ammonium CompoundsStatic ElectricityWaterMacrocyclic CompoundsQuaternary Ammonium CompoundsWaterhost-guest systemsneuromuscular blockerspillararenesequestration agentultratight binding

Identifiers

PMID32413198
PMCPMC7487980

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.