ArticleThe Journal of clinical endocrinology and metabolism2020
Unique Metabolic Features of Adults Discordant for Indices of Insulin Resistance.
Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed.
- Precision Approaches in Diabetes Prevention: Towards a Clustering Approach With More Phenotypical Granularity.The Journal of clinical endocrinology and metabolism · 2026Article
- Metabolic Phenotypes, Genotypes, and Gut Microbiome Signatures in Obesity: Implications for Precision Nutrition Strategies in Type 2 Diabetes Prevention.Nutrition reviews · 2026Review
- Distinct gut microbiota and metabolome features of tissue-specific insulin resistance in overweight and obesity.Gut microbes · 2025Article
- Circulating BCKAs are closely associated with adipose tissue insulin resistance in type 2 diabetes.Diabetology & metabolic syndrome · 2025Article
- Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4-MAPK pathway in T2DM mice.Renal failure · 2023Article
- Metabolic phenotyping in people living with obesity: Implications for dietary prevention.Reviews in endocrine & metabolic disorders · 2023Review
- Correlation between serum uric acid and body fat distribution in patients with MAFLD.BMC endocrine disorders · 2023Article
- Adipose Tissue Insulin Resistance Is Not Associated With Changes in the Degree of Obesity in Children and Adolescents.The Journal of clinical endocrinology and metabolism · 2023Observational
- Adipose Tissue Insulin Resistance Is Positively Associated With Serum Uric Acid Levels and Hyperuricemia in Northern Chinese Adults.Frontiers in endocrinology · 2022Article
- Changes in the Leptin to Adiponectin Ratio Are Proportional to Weight Loss After Meal Replacement in Adults With Severe Obesity.Frontiers in nutrition · 2022Article
- Adipose Tissue Insulin Resistance is Closely Associated with Metabolic Syndrome in Northern Chinese Populations.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Unique Metabolic Features of Adults Discordant for Indices of Insulin Resistance.The Journal of clinical endocrinology and metabolism · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
purposeHomeostatic Model Assessment for Insulin Resistance (HOMA-IR) and Adipose Insulin Resistance index (ADIPO-IR) values are often concordant. In this study we evaluated whether there are groups discordant for HOMA-IR and ADIPOpalmitate-IR and, if so, what are their defining characteristics.
methodsThe body composition, basal metabolic rate (BMR), fasting plasma lipids, insulin, glucose, and free fatty acid (FFA) palmitate concentrations data of 466 volunteers from previous research studies were abstracted and analyzed. The middle 2 population quartiles for HOMA-IR and Adipose Insulin Resistance index palmitate concentration (ADIPOpalmitate-IR) defined medium HOMA-IR and ADIPOpalmitate-IR (MH and MA), the top and bottom quartiles were defined as high/low HOMA (HH/LH), and high/low ADIPOpalmitate as HA/LA. Because ADIPOpalmitate-IR was significantly greater in women than in men, we established sex-specific quartiles for each index. We identified groups discordant for HOMA-IR and ADIPO-IR (HHMA, LHMA, MHHA, and MHLA).
resultsBody fat and fasting triglycerides (TGs) were significantly greater with higher indices in the concordant groups (HHHA > MHMA > LHLA). MHHA differed from MHLA by visceral fat (P < .01) and fasting TGs (P < .05), whereas HHMA differed (P < .01) from LHMA by BMR. By multivariate regression, the group factor contributed to BMR (P < .01) and visceral fat (P < .05).
conclusionsAdults discordant for HOMA-IR and ADIPO-IR have unique features including differences in visceral fat, TGs, and BMR. This suggests different forms of insulin resistance are present, which should be considered when studying insulin resistance in the future.
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