Evidence map›Paper›PMID 32413107›Full record

ArticleRheumatology (Oxford, England)2020

Impact of ICD10 and secular changes on electronic medical record rheumatoid arthritis algorithms.

Sicong Huang, Jie Huang, Tianrun Cai, Kumar P Dahal, Andrew Cagan, Zeling He, Jacklyn Stratton, Isaac Gorelik, Chuan Hong, Tianxi Cai and 1 more

Abstract readValidation Study
In one paragraph

Article in Rheumatology (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sicong HuangDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.
Jie HuangDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.
Tianrun CaiDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.
Kumar P DahalDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.
Andrew CaganDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.
Zeling HeDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.
Jacklyn StrattonDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.
Isaac GorelikDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.
Chuan HongDepartment of Biomedical Informatics, Harvard Medical School.
Tianxi CaiDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.
Katherine P LiaoDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.

Funding

MECHANISMS OF ARTHRITIC &DERMATOLOGY DISORDERST32AR007530 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Michael B. Brenner, Ellen M Gravallese · 1986 to 2026
$10.4M
VERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYticsP30AR072577 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Daniel Hal Solomon · 2017 to 2026
$9.8M
NIAMS NIH HHS P30 AR072577NIAMS NIH HHS T32 AR007530
6 · The paper itself

Abstract

objectiveThe objective of this study was to compare the performance of an RA algorithm developed and trained in 2010 utilizing natural language processing and machine learning, using updated data containing ICD10, new RA treatments, and a new electronic medical records (EMR) system.

methodsWe extracted data from subjects with ≥1 RA International Classification of Diseases (ICD) codes from the EMR of two large academic centres to create a data mart. Gold standard RA cases were identified from reviewing a random 200 subjects from the data mart, and a random 100 subjects who only have RA ICD10 codes. We compared the performance of the following algorithms using the original 2010 data with updated data: (i) a published 2010 RA algorithm; (ii) updated algorithm, incorporating ICD10 RA codes and new DMARDs; and (iii) published algorithm using ICD codes only, ICD RA code ≥3.

resultsThe gold standard RA cases had mean age 65.5 years, 78.7% female, 74.1% RF or antibodies to cyclic citrullinated peptide (anti-CCP) positive. The positive predictive value (PPV) for ≥3 RA ICD was 54%, compared with 56% in 2010. At a specificity of 95%, the PPV of the 2010 algorithm and the updated version were both 91%, compared with 94% (95% CI: 91, 96%) in 2010. In subjects with ICD10 data only, the PPV for the updated 2010 RA algorithm was 93%.

conclusionThe 2010 RA algorithm validated with the updated data with similar performance characteristics as the 2010 data. While the 2010 algorithm continued to perform better than the rule-based approach, the PPV of the latter also remained stable over time.

Indexed as

Arthritis, RheumatoidInternational Classification of DiseasesAlgorithmsElectronic Health RecordsHumanselectronic medical recordmachine learningrheumatoid arthritis

Identifiers

PMID32413107
PMCPMC7733719

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.