ArticlePloS one2020
Diffusion MRI reveals in vivo and non-invasively changes in astrocyte function induced by an aquaporin-4 inhibitor.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 54 citations in OpenAlex.
- Synaptic micromechanics and brain softening as a mechanobiological hypothesis for Alzheimer's disease.Frontiers in neuroscience · 2026Article
- Contribution of white matter microstructure to diffusion tensor image analysis along perivascular space in obstructive sleep apnea.Japanese journal of radiology · 2025Article
- The Glymphatic System and Obesity: A Diffusion Tensor Imaging ALPS Study.Biomedicines · 2025Article
- Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer's disease.Translational neurodegeneration · 2025Review
- Mapping grey and white matter activity in the human brain with isotropic ADC-fMRI.Nature communications · 2025Article
- Aquaporin-4 inhibition alters cerebral glucose dynamics predominantly in obese animals: an MRI study.Scientific reports · 2025Article
- Diffusion Tensor Imaging in Neurofluids.Neuroimaging clinics of North America · 2025Review
- Apparent Diffusion Coefficient fMRI shines light on white matter resting-state connectivity compared to BOLD.Communications biology · 2025Article
- Astrocyte-mediated inflammatory responses in traumatic brain injury: mechanisms and potential interventions.Frontiers in immunology · 2025Review
- Glymphatic system function in patients with ischemic stroke evaluated by the DTI-ALPS method: a comprehensive review.Frontiers in neurology · 2025Review
- Perivascular and parenchymal fluid characteristics are related to age and cognitive performance across the lifespan.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Evaluating the dependence of ADC-fMRI on haemodynamics in breath-hold and resting-state conditions.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- From Brownian motion to virtual biopsy: a historical perspective from 40 years of diffusion MRI.Japanese journal of radiology · 2024Review
- Article
- Relationship between regional volume changes and water diffusion in fixed marmoset brains: an in vivo and ex vivo comparison.Scientific reports · 2024Article
- Diffusion magnetic resonance imaging of cerebrospinal fluid dynamics: Current techniques and future advancements.NMR in biomedicine · 2024Review
- Immediate effect of quadri-pulse stimulation on human brain microstructures and functions.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Vascular risk factors and astrocytic marker for the glymphatic system activity.La Radiologia medica · 2023Article
- The Brain's Glymphatic System: Drawing New Perspectives in Neuroscience.Brain sciences · 2023Article
- Measuring water exchange on a preclinical MRI system using filter exchange and diffusion time dependent kurtosis imaging.Magnetic resonance in medicine · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Glymphatic System (GS) has been proposed as a mechanism to clear brain tissue from waste. Its dysfunction might lead to several brain pathologies, including the Alzheimer's disease. A key component of the GS and brain tissue water circulation is the astrocyte which is regulated by acquaporin-4 (AQP4), a membrane-bound water channel on the astrocytic end-feet. Here we investigated the potential of diffusion MRI to monitor astrocyte activity in a mouse brain model through the inhibition of AQP4 channels with TGN-020. Upon TGN-020 injection, we observed a significant decrease in the Sindex, a diffusion marker of tissue microstructure, and a significant increase of the water diffusion coefficient (sADC) in cerebral cortex and hippocampus compared to saline injection. These results indicate the suitability of diffusion MRI to monitor astrocytic activity in vivo and non-invasively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.