ArticlePloS one2020
Association of subclinical atherosclerosis with echocardiographic indices of cardiac remodeling: The Framingham Study.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Electrocardiogram-based deep learning score for coronary artery calcification reclassifies cardiovascular risk and identifies screening candidates.BMC medical informatics and decision making · 2026Article
- Coronary Artery Calcium for Risk Stratification of Heart Failure Mortality: The Coronary Artery Calcium Consortium.Journal of cardiac failure · 2025Article
- Impact of coronary artery calcium on progression of diastolic dysfunction: a cohort study.BMC medicine · 2025Article
- Are Non-Invasive Modalities for the Assessment of Atherosclerosis Useful for Heart Failure Predictions?International journal of molecular sciences · 2023Review
- Artificial Intelligence-Enabled ECG Algorithm for the Prediction of Coronary Artery Calcification.Frontiers in cardiovascular medicine · 2022Article
- Association of left ventricular diastolic function with coronary artery calcium score: A Project Baseline Health Study.Journal of cardiovascular computed tomographyObservational
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundIt is well established that coronary artery disease progresses along with myocardial disease. However, data on the association between coronary artery calcium (CAC) and echocardiographic variables are lacking. METHODS AND
resultsAmong 2,650 Framingham Study participants (mean age 51 yrs, 48% women; 40% with CAC>0), we related CT-based CAC score to left ventricular (LV) mass index (LVMi), LV ejection fraction (LVEF), E/e', global longitudinal strain (GLS), left atrial emptying fraction (LAEF), and aortic root diameter (AoR), using multivariable-adjusted generalized linear models. CAC score (independent variable) was used as log-transformed continuous [ln(CAC+1)] and as a categorical (0, 1-100, and ≥101) variable. Adjusting for standard risk factors, higher CAC score was associated with higher LVMi and AoR (βLVMI per 1-SD increase 0.012, βAoR 0.008; P<0.05, for both). Participants with 1≤CAC≤100 and those with CAC≥101 had higher AoR (βAoR 0.013 and 0.020, respectively, P = 0.01) than those with CAC = 0. CAC score was not significantly associated with LVEF, E/e', GLS or LAEF. Age modified the association of CAC score with AoR; higher CAC scores were associated with larger AoR more strongly in older (>58 years; βAoR0.0042;P<0.007) than in younger (≤58 years) participants (βAoR0.0027;P<0.03).
conclusionsWe observed that subclinical atherosclerosis was associated with ventricular and aortic remodeling. The prognostic significance of these associations warrants evaluation in additional mechanistic studies.
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