ArticlePloS one2020
Pulmonary ductal coarctation and left pulmonary artery interruption; pathology and role of neural crest and second heart field during development.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Late-onset hypercyanotic spells in duct-dominant Tetralogy of Fallot with pulmonary atresia from juxtaductal PDA-LPA stenosis: CT angiography for preoperative mapping.Journal of surgical case reports · 2026Article
- Successful balloon angioplasty of right pulmonary coarctation with left pulmonary artery interruption in a cat: a long-term outcome follow-up case report.The Journal of veterinary medical science · 2025Article
- Origins of Aortic Coarctation: A Vascular Smooth Muscle Compartment Boundary Model.Journal of developmental biology · 2025Article
- Predicting Risk for Patent Ductus Arteriosus in the Neonate: A Machine Learning Analysis.Medicina (Kaunas, Lithuania) · 2025Article
- Development of autonomic innervation at the venous pole of the heart: bridging the gap from mice to human.Journal of translational medicine · 2025Article
- Total Anomalous Pulmonary Venous Connections, Human Genetics.Advances in experimental medicine and biology · 2024Review
- Left Pulmonary Artery Coarctation Associated with Pneumonia and Pulmonary Hypertension in a Cat.Veterinary sciences · 2021Article
- Pulmonary ductal coarctation: An entity associated with congenital heart defects involving the right ventricle outflow tract.Journal of cardiac surgery · 2021Article
- Ventricular Septation and Outflow Tract Development in Crocodilians Result in Two Aortas with Bicuspid Semilunar Valves.Journal of cardiovascular development and disease · 2021Article
- Article
- Isolated Dissection of the Ductus Arteriosus Associated with Sudden Unexpected Intrauterine Death.Journal of cardiovascular development and disease · 2021Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIn congenital heart malformations with pulmonary stenosis to atresia an abnormal lateral ductus arteriosus to left pulmonary artery connection can lead to a localised narrowing (pulmonary ductal coarctation) or even interruption We investigated embryonic remodelling and pathogenesis of this area. MATERIAL AND
methodsNormal development was studied in WntCre reporter mice (E10.0-12.5) for neural crest cells and Nkx2.5 immunostaining for second heart field cells. Data were compared to stage matched human embryos and a VEGF120/120 mutant mouse strain developing pulmonary atresia.
resultsNormal mouse and human embryos showed that the mid-pharyngeal endothelial plexus, connected side-ways to the 6th pharyngeal arch artery. The ventral segment formed the proximal pulmonary artery. The dorsal segment (future DA) was solely surrounded by neural crest cells. The ventral segment had a dual outer lining with neural crest and second heart field cells, while the distal pulmonary artery was covered by none of these cells. The asymmetric contribution of second heart field to the future pulmonary trunk on the left side of the aortic sac (so-called pulmonary push) was evident. The ventral segment became incorporated into the pulmonary trunk leading to a separate connection of the left and right pulmonary arteries. The VEGF120/120 embryos showed a stunted pulmonary push and a variety of vascular anomalies. SUMMARY: Side-way connection of the DA to the left pulmonary artery is a congenital anomaly. The primary problem is a stunted development of the pulmonary push leading to pulmonary stenosis/atresia and a subsequent lack of proper incorporation of the ventral segment into the aortic sac. Clinically, the aberrant smooth muscle tissue of the ductus arteriosus should be addressed to prohibit development of severe pulmonary ductal coarctation or even interruption of the left pulmonary artery.
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