Trial reportOptometry and vision science : official publication of the American Academy of Optometry2020
Baseline and Clinical Factors Associated with Response to Amblyopia Treatment in a Randomized Clinical Trial.
Trial report in Optometry and vision science : official publication of the American Academy of Optometry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02365090 (Binocular iPad Sub-Study; Suppression in Amblyopia), which is not on this map. Cited by 24 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Binocular iPad Sub-Study; Suppression in Amblyopia
Who cites it
24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Short- and long-term outcomes of binocular gaming versus patching in childhood amblyopia: a systematic review and meta-analysis.European journal of pediatrics · 2026Pooled it
- Meta-analysis of acupuncture combined therapies for amblyopia: efficacy and safety insights.Frontiers in medicine · 2025Pooled it
- Computer-Assisted Visual Training in Children and Adolescents with Developmental Visual Disorders.Deutsches Arzteblatt international · 2023Pooled it
- Binocular versus standard occlusion or blurring treatment for unilateral amblyopia in children aged three to eight years.The Cochrane database of systematic reviews · 2022Pooled it
- Analysis of patient adherence to emerging treatment tools for improving visual functions in amblyopia: A systematic review and meta-analysis.Journal of optometryPooled it
- Randomized clinical trial of streaming dichoptic movies versus patching for treatment of amblyopia in children aged 3 to 7 years.Scientific reports · 2022Trial
- A pilot randomized trial of contrast-rebalanced binocular treatment for deprivation amblyopia.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2020Trial
- A randomized clinical trial of contrast increment protocols for binocular amblyopia treatment.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2020Trial
- Video Game-Based Interventions for Visual Rehabilitation in Childhood Amblyopia: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2026Review
- Systematic Review and Meta-Analysis of RCTs on Efficacy of Conventional vs. Emerging Treatments for Amblyopia.Life (Basel, Switzerland) · 2026Review
- Baseline and outcome stereoacuity of children with anisometropic amblyopia undergoing dichoptic amblyopia treatment.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2025Article
- Assessing Previous Strategies and Presenting a Novel Smart Glasses to Enhance Adherence to Amblyopia Therapy in Children.Patient preference and adherence · 2025Review
- Efficacy of Dichoptic Treatment vs Eye Patching in Pediatric Patients with Amblyopia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Clinical ophthalmology (Auckland, N.Z.) · 2025Review
- Visual Performance of Children with Amblyopia after 6 Weeks of Home-Based Dichoptic Visual Training.Children (Basel, Switzerland) · 2024Article
- Harnessing brain plasticity to improve binocular vision in amblyopia: An evidence-based update.European journal of ophthalmology · 2024Review
- Novel Quantitative Contrast Sensitivity Function Enhances the Prediction of Treatment Outcome and Recurrence in Amblyopia.Investigative ophthalmology & visual science · 2024Article
- Risk of recurrence after cessation of dichoptic, binocular treatment of amblyopia.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2023Article
- Amblyopia and the whole child.Progress in retinal and eye research · 2023Review
- Current directions in visual perceptual learning.Nature reviews psychology · 2022Article
- Reasons why we might want to question the use of patching to treat amblyopia as well as the reliance on visual acuity as the primary outcome measure.BMJ open ophthalmology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
significanceWe sought to identify baseline and clinical factors that were predictive of the response to amblyopia treatment. We report that binocular amblyopia treatment may be especially effective for moderate amblyopia in orthotropic children. PURPOSE: We previously reported results from the primary cohort (n = 28) enrolled in a randomized clinical trial (NCT02365090), which found that binocular amblyopia treatment was more effective than patching. Enrollment of an additional 20 children was pre-planned to provide the opportunity to examine factors that may be predictive of response to amblyopia treatment.
methodsForty-eight children (4 to 10 years old) were enrolled, with 24 randomized to contrast-rebalanced binocular game treatment (1 hour a day, 5 days a week) and 24 to patching treatment (2 hours a day, 7 days a week). The primary outcome was change in amblyopic eye best-corrected visual acuity at the 2-week visit. Baseline factors examined were age at enrollment, visual acuity, stereoacuity, and suppression. Clinical factors were etiology, age at diagnosis, prior treatment, and ocular alignment.
resultsAt 2 weeks, visual acuity improvement was significantly greater with the binocular game than patching. Children with moderate amblyopia and orthotropia had more visual acuity improvement with binocular game play than did those with severe amblyopia. In addition, children who spent more time playing the binocular game had more improvement. We were not able to confidently identify any baseline or clinical factors that were associated with response to patching treatment.
conclusionsBinocular amblyopia treatment was more effective among orthotropic children with moderate amblyopia than among children with microtropia or severe amblyopia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.