Evidence map›Paper›PMID 32412807›Full record

ArticleThe Journal of international medical research2020

Atorvastatin protects against postoperative neurocognitive disorder via a peroxisome proliferator-activated receptor-gamma signaling pathway in mice.

Yinan Yang, Changwei Wei, Jinhu Liu, Danxu Ma, Chao Xiong, Dandan Lin, Anshi Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Biomedicines · 2025
    Article
  3. Review
  4. Review
  5. PET Tracing of Biodistribution for Orally AdministeredJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yinan YangDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Changwei WeiDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Jinhu LiuDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Danxu MaDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Chao XiongDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Dandan LinDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Anshi WuDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-2353-2184
Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePostoperative neurocognitive disorder (PND) is a main complication that is commonly seen postoperatively in elderly patients. The underlying mechanism remains unclear, although neuroinflammation has been increasingly observed in PND. Atorvastatin is a pleiotropic agent with proven anti-inflammatory effects. In this study, we investigated the effects of atorvastatin on a PND mouse model after peripheral surgery. MATERIAL AND

methodsThe mice were randomized into five groups. The PND models were established, and an open field test and fear condition test were performed. Hippocampal inflammatory cytokine expression was determined using ELISA. Peroxisome proliferator-activated receptor-gamma (PPARγ) expression in the hippocampus was tested using qRT-PCR and western blot analysis.

resultsOn day 1 after surgery, inflammatory cytokines such as tumor necrosis factor-α, interleukin-1β, and interleukin-6 showed a significant increase in the hippocampus, with prominent cognitive impairment. Atorvastatin treatment improved cognitive function in the mouse model, attenuated neuroinflammation, and increased PPARγ expression in the hippocampus. However, treatment with the PPARγ antagonist GW9662 partially reversed the protective effects of atorvastatin.

conclusionsThese results indicated that atorvastatin improves several hippocampal functions and alleviates inflammation in PND mice after surgery, probably through a PPARγ-involved signaling pathway.

Indexed as

AnimalsAtorvastatinDisease Models, AnimalHippocampusHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiceMice, Inbred C57BLPostoperative Cognitive ComplicationsPPAR gammaSignal TransductionAtorvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsPPAR gammaPparg protein, mouseatorvastatincognitive impairmenthippocampal functionsinflammationneuroinflammationPostoperative neurocognitive disorderPPARγ

Identifiers

PMID32412807
PMCPMC7232118
OpenAlexW3024884216

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.