ArticleeLife2020
Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Population-level geometric filtering generates motion-coherence selectivity in the retina.Science advances · 2026Article
- Eyewire II - A connectomic resource for resolving cell types and circuits of the mouse retina.bioRxiv : the preprint server for biology · 2026Article
- Bipolar cell networks underlying steady-state intensity encoding in intrinsically photosensitive retinal ganglion cells.iScience · 2026Article
- The mysterious middlemen making your vision pop: understanding the function of amacrine cells.The Journal of physiology · 2025Review
- Specific retinal neurons regulate context-dependent defensive responses to visual threat.PNAS nexus · 2024Article
- The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Layers of inhibitory networks shape receptive field properties of AII amacrine cells.Cell reports · 2023Article
- Using optogenetics to dissect rod inputs to OFF ganglion cells in the mouse retina.Frontiers in ophthalmology · 2023Article
- Functional properties of GABAFrontiers in ophthalmology · 2023Article
- New insights into retinal circuits through EM connectomics: what we have learnt and what remains to be learned.Frontiers in ophthalmology · 2023Review
- Glial Bmal1 role in mammalian retina daily changes.Scientific reports · 2022Article
- Dendritic Morphology of an Inhibitory Retinal Interneuron Enables Simultaneous Local and Global Synaptic Integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Inhibitory inputs to an inhibitory interneuron: Spontaneous postsynaptic currents and GABAThe European journal of neuroscience · 2022Article
- Dendro-somatic synaptic inputs to ganglion cells contradict receptive field and connectivity conventions in the mammalian retina.Current biology : CB · 2022Article
- Dopamine D1 and D4 receptors contribute to light adaptation in ON-sustained retinal ganglion cells.Journal of neurophysiology · 2021Article
- Photoreceptive Ganglion Cells Drive Circuits for Local Inhibition in the Mouse Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Computational and Molecular Properties of Starburst Amacrine Cell Synapses Differ With Postsynaptic Cell Type.Frontiers in cellular neuroscience · 2021Article
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Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Night vision in mammals depends fundamentally on rod photoreceptors and the well-studied rod bipolar (RB) cell pathway. The central neuron in this pathway, the AII amacrine cell (AC), exhibits a spatially tuned receptive field, composed of an excitatory center and an inhibitory surround, that propagates to ganglion cells, the retina's projection neurons. The circuitry underlying the surround of the AII, however, remains unresolved. Here, we combined structural, functional and optogenetic analyses of the mouse retina to discover that surround inhibition of the AII depends primarily on a single interneuron type, the NOS-1 AC: a multistratified, axon-bearing GABAergic cell, with dendrites in both ON and OFF synaptic layers, but with a pure ON (depolarizing) response to light. Our study demonstrates generally that novel neural circuits can be identified from targeted connectomic analyses and specifically that the NOS-1 AC mediates long-range inhibition during night vision and is a major element of the RB pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.