ArticleeLife2020
Automated task training and longitudinal monitoring of mouse mesoscale cortical circuits using home cages.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Real-time closed-loop feedback system for mouse mesoscale cortical signal and movement control.eLife · 2026Article
- Toward video-LLM driven workflow for behavioral segmentation and scoring in mice performing a skilled water-reaching task: an evaluation of recent LLM models.Neurophotonics · 2026Article
- The Training Village: an open platform for continuous testing of rodents in cognitive tasks.bioRxiv : the preprint server for biology · 2026Article
- Development of an automated approach for investigating social learning in mice.Frontiers in behavioral neuroscience · 2026Article
- Article
- Bridging the gap: umIT makes complex imaging data accessible to scientists of all backgrounds.Neurophotonics · 2025Article
- Automated head-fixation training system with high levels of animal participation in psychoacoustic tasks.PloS one · 2025Article
- Auditory discrimination learning differentially modulates neural representation in auditory cortex subregions and inter-areal connectivity.Cell reports · 2024Article
- Magnetic voluntary head-fixation in transgenic rats enables lifespan imaging of hippocampal neurons.Nature communications · 2024Article
- FABEL: Forecasting Animal Behavioral Events with Deep Learning-Based Computer Vision.bioRxiv : the preprint server for biology · 2024Article
- Meso-Py: Dual Brain Cortical Calcium Imaging in Mice during Head-Fixed Social Stimulus Presentation.eNeuro · 2023Article
- Advances in cellular resolution microscopy for brain imaging in rats.Neurophotonics · 2023Review
- Multiregion neuronal activity: the forest and the trees.Nature reviews. Neuroscience · 2022Review
- Refinements to rodent head fixation and fluid/food control for neuroscience.Journal of neuroscience methods · 2022Review
- Chronic CaeLife · 2022Article
- Inflammation-driven brain and gut barrier dysfunction in stress and mood disorders.The European journal of neuroscience · 2022Review
- Efficient training approaches for optimizing behavioral performance and reducing head fixation time.PloS one · 2022Article
- Chronic, cortex-wide imaging of specific cell populations during behavior.Nature protocols · 2021Article
- Article
- TailTimer: A device for automating data collection in the rodent tail immersion assay.PloS one · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
We report improved automated open-source methodology for head-fixed mesoscale cortical imaging and/or behavioral training of home cage mice using Raspberry Pi-based hardware. Staged partial and probabilistic restraint allows mice to adjust to self-initiated headfixation over 3 weeks' time with ~50% participation rate. We support a cue-based behavioral licking task monitored by a capacitive touch-sensor water spout. While automatically head-fixed, we acquire spontaneous, movement-triggered, or licking task-evoked GCaMP6 cortical signals. An analysis pipeline marked both behavioral events, as well as analyzed brain fluorescence signals as they relate to spontaneous and/or task-evoked behavioral activity. Mice were trained to suppress licking and wait for cues that marked the delivery of water. Correct rewarded go-trials were associated with widespread activation of midline and lateral barrel cortex areas following a vibration cue and delayed frontal and lateral motor cortex activation. Cortical GCaMP signals predicted trial success and correlated strongly with trial-outcome dependent body movements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.