Evidence map›Paper›PMID 32411796›Full record

ArticleJournal of immunology research2020

miR-24-3p/KLF8 Signaling Axis Contributes to LUAD Metastasis by Regulating EMT.

Pengyu Jing, Nianlin Xie, Nan Zhao, Ximing Zhu, Pei Li, Guizhou Gao, Haizhou Dang, Zhongping Gu

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Pengyu JingDepartment of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi'an 710038, China.ORCID https://orcid.org/0000-0001-7378-4887
Nianlin XieDepartment of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi'an 710038, China.ORCID https://orcid.org/0000-0002-6892-4942
Nan ZhaoDepartment of Public Health, Xi'an Medical University, Xi'an 710021, China.ORCID https://orcid.org/0000-0001-7740-5186
Ximing ZhuDepartment of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi'an 710038, China.ORCID https://orcid.org/0000-0003-0877-6746
Pei LiDepartment of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi'an 710038, China.ORCID https://orcid.org/0000-0002-6710-2816
Guizhou GaoDepartment of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi'an 710038, China.ORCID https://orcid.org/0000-0003-1880-7892
Haizhou DangDepartment of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi'an 710038, China.ORCID https://orcid.org/0000-0003-1949-0399
Zhongping GuDepartment of Thoracic Surgery, The Second Affiliated Hospital, Air Force Medical University, Xi'an 710038, China.ORCID https://orcid.org/0000-0002-7395-7888
People 's Liberation Army 451 Hospital · CNXi'an Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reprogramming of the tumor immune microenvironment is a salient feature during metastasis in LUAD. miR-24-3p and KLF8, which are key regulators of the tumor immune microenvironment, had been proved to show metastasis-promoting property in LUAD. However, whether miR-24-3p could regulate LUAD metastasis by targeting KLF8 remains unclear. This study explored the functions and mechanisms of miR-24-3p/KLF8 signaling in advanced LUAD. The expression level of miR-24-3p and KLF8 were tested in LUAD patients, and the corelation of miR-24-3p and KLF8 was evaluated. The interaction of miR-24-3p and KLF8 was demonstrated by luciferase reporter activity assay,

Indexed as

A549 CellsAdenocarcinoma of LungAnimalsAntigens, CDCadherinsCell ProliferationDown-RegulationEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateKruppel-Like Transcription FactorsLungLung NeoplasmsMaleMiceAntigens, CDCadherinsCDH1 protein, humanKLF8 protein, humanKruppel-Like Transcription FactorsMicroRNAsMIRN24 microRNA, humanSNAI1 protein, humanSnail Family Transcription Factors

Identifiers

PMID32411796
PMCPMC7204180
OpenAlexW3021645531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.