Evidence map›Paper›PMID 32411786›Full record

ArticleJournal of immunology research2020

Perivascular Lymphocyte Clusters Induced by Gastric Subserous Layer Vaccination Mediate Optimal Immunity against Helicobacter through Facilitating Immune Cell Infiltration and Local Antibody Response.

Chupeng Hu, Wei Liu, Ningyin Xu, An Huang, Zhiqin Zeng, Shuanghui Luo, Zhenxing Zhang, Menghui Fan, Feng Ye, Tao Xi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Chupeng HuSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Wei LiuSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Ningyin XuSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
An HuangSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Zhiqin ZengSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Shuanghui LuoSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Zhenxing ZhangSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Menghui FanSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Feng YeDepartment of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Tao XiSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.ORCID https://orcid.org/0000-0001-8065-2639
Yingying XingSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.ORCID https://orcid.org/0000-0001-5566-3096
China Pharmaceutical University · CNJiangsu Province Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMATERIALS AND

methodsWe performed the laparotomy to access the stomach and injected alum-based vaccine into the gastric subserous layer (GSL). At 28 days post vaccination, a parabiosis mouse model along with depletion of anti-CD90.2 antibody was employed to explore the function of perivascular lymphocyte clusters in recall responses. The composition of the gastric lymphocyte clusters was analyzed by immunofluorescence staining. Antibody responses were detected using ELISA. Gastric lymphocytes were analyzed using flow cytometry.

resultsGSL vaccination induced the formation of new vessels in the inflamed region. These new vessels were different from native vessels in that they were generally accompanied by perivascular lymphocyte clusters that mainly consisted of CD90-expressing cells. Additionally, histological analysis revealed the presence of CD4

conclusionsOur research demonstrates that

Indexed as

Adjuvants, ImmunologicAlum CompoundsAnimalsBacterial VaccinesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDisease Models, AnimalFemaleGastric MucosaHelicobacter InfectionsHelicobacter pyloriHumansImmunologic MemoryInjections, IntralesionalMiceThy-1 AntigensAdjuvants, ImmunologicAlum Compoundsaluminum sulfateBacterial VaccinesThy-1 AntigensVaccines, Subunit

Identifiers

PMID32411786
PMCPMC7201474
OpenAlexW2999738123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.