Evidence map›Paper›PMID 32411776›Full record

ReviewAnnals of translational medicine2020

Prognostic value of the albumin-bilirubin grade in patients with hepatocellular carcinoma and other liver diseases.

Dayun Feng, Mengmeng Wang, Jie Hu, Songlun Li, Shoujie Zhao, Huichen Li, Lei Liu

Abstract readReview
In one paragraph

Review in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Review
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  7. Impact of Child Pugh B Stage for the Treatment of Advanced HCC.Journal of hepatocellular carcinoma · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Dayun FengDepartment of surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.
Mengmeng WangDepartment of Drug and Equipment, Aeromedicine Identification and Training Centre of Air Force, Xi'an 710069, China.
Jie HuDepartment of Clinical laboratory, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.
Songlun LiDepartment of Blood Transfusion, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China.
Shoujie ZhaoDepartment of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.
Huichen LiThe State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China.
Lei LiuDepartment of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the most commonly used systems for grading liver function in hepatocellular carcinoma (HCC) patients is the Child-Pugh (CP) score. However, the CP scoring system is not without its shortcomings: for example, the cut-off values for the parameters are calculated arbitrarily and the assessment of ascites and hepatic encephalopathy is subjective. More recently, an alternative to traditional CP grade has emerged in the form of albumin-bilirubin (ALBI) grade. The predictive value provided for HCC patients by the ALBI grade is comparable to that of the CP grade; however, it can also surpass CP grade by greatly reducing subjectivity and further subdividing CP A patients into several different groups, thus improving the prognosis judgment and helping to inform clinicians' optimal decision-making. The application of the ALBI grade into currently used HCC staging systems such as the Barcelona Clinic Liver Cancer (BCLC) staging system, the Cancer of the Liver Italian Program (CLIP) staging system, and the Japan Integrated Staging (JIS) score, etc., as well as newly produced systems like the ALBI-PLT grade, the ALBI and progression disease (ALBI-PD) grade and Modified Intermediate Stage of Liver Cancer (MICAN) criteria, greatly elevates prognostic power.

Indexed as

albumin-bilirubin gradeChild-Pugh score (CP score)Hepatocellular carcinoma (HCC)liver diseasesprognostic value

Identifiers

PMID32411776
PMCPMC7214886

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.