Evidence map›Paper›PMID 32411762›Full record

ArticleAnnals of translational medicine2020

Comparison between Child-Pugh score and Albumin-Bilirubin grade in the prognosis of patients with HCC after liver resection using time-dependent ROC.

Shoujie Zhao, Mengmeng Wang, Zhenyu Yang, Kai Tan, Desha Zheng, Xilin Du, Lei Liu

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Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

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38citing papers in PubMed
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38 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Shoujie ZhaoDepartment of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.
Mengmeng WangDepartment of Drug and Equipment, Aeromedicine Identification and Training Centre of Air Force, Xi'an 710069, China.
Zhenyu YangDepartment of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.
Kai TanDepartment of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.
Desha ZhengDepartment of Nursing, Fourth Military Medical University, Xi'an 710032, China.
Xilin DuDepartment of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.
Lei LiuDepartment of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsThe Child-Pugh score is a scoring system used to measure liver function and predict postoperative outcomes in patients with hepatocellular carcinoma (HCC). Recently, the Albumin-Bilirubin (ALBI) grade has been proposed for the evaluation of hepatic reserve function in HCC. This study aimed to assess and compare the capability of ALBI grade and Child-Pugh score in predicting overall survival (OS).

methodsA total of 196 consecutive HCC patients who treated with hepatectomy were enrolled in this retrospective study. The prognostic values of ALBI grade and Child-Pugh score in predicting postoperative OS were respectively estimated using the Kaplan-Meier method and time-dependent receiver operating curves (ROC). Univariate and multivariate Cox regression analyses were performed to investigate the prognostic factors for OS.

resultsStratified by the Albumin-Bilirubin (ALBI) system, there were 81 (41.3%) patients with grade 1 and 115 (58.7%) patients with grade 2. The cumulative 1-, 3-, 5-year OS rates in patients with ALBI-1 were 82.7%, 51.5% and 35.5%, respectively. For patients with ALBI-2, the cumulative 1-, 3-, 5-year OS rates were 57.6%, 19.4% and 0%, respectively. Based on the Child-Pugh classification, 136 (69.4%) patients had a score of 5, and 60 (30.6%) patients had a score of 6. Patients with Child-Pugh-A5 showed a better OS than those with Child-Pugh-A6, with respective OS at 1, 3 and 5 years (72.7%, 29.2%, 20.3%

conclusionsALBI grade supplied better prognostic performance and distribution of liver function than Child-Pugh score in stratifying prognosis for HCC patients treated by hepatectomy. These results declared that ALBI grade could be an alternative liver function grading system for stratification in patients with HCC.

Indexed as

Albumin-Bilirubin grade (ALBI grade)Child-Pugh scorehepatocellular carcinoma (HCC)liver resectiontime-dependent receiver operating characteristic curve

Identifiers

PMID32411762
PMCPMC7214905

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.