ArticleAnnals of translational medicine2020
Metabolomic alterations associated with Kallmann syndrome.
Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Seminal plasma metabolomics signatures of normosmic congenital hypogonadotropic hypogonadism.Heliyon · 2023Article
- Seminal plasma metabolomics and lipidomics profiling to identify signatures of pituitary stalk interruption syndrome.Orphanet journal of rare diseases · 2022Article
- Seminal Plasma Lipidomics Profiling to Identify Signatures of Kallmann Syndrome.Frontiers in endocrinology · 2021Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study was conducted to identify potential seminal plasma metabolic markers associated with disease activity in Kallmann syndrome (KS).
methodsWe collected medical records and seminal plasma samples from 17 KS patients and 20 age-matched healthy controls (HC) and performed metabolomics analysis using the UPLC-QTOF-MS method.
resultsPartial least squares discriminant analysis (PLS-DA) showed that the metabolomics profile of KS patients was clearly separated from HC. Statistical analysis of the data indicates that there are differential metabolites between KS patients and HC. The main metabolic pathways focus on linoleic acid (LA) metabolism, Glycerophospholipid metabolism.
conclusionsThe seminal plasma metabolomics profile of KS patients has changed. Glycerophospholipids and LA are promising biomarkers for KS diagnosis.
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