Evidence map›Paper›PMID 32411675›Full record

ArticleFrontiers in chemistry2020

Oxygen-Sufficient Nanoplatform for Chemo-Sonodynamic Therapy of Hypoxic Tumors.

Biying Huang, Sijie Chen, Wenjing Pei, Yan Xu, Zichao Jiang, Chengcheng Niu, Long Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  15. MnOFrontiers in bioengineering and biotechnology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Biying HuangDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Sijie ChenDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Wenjing PeiDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Yan XuDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Zichao JiangDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Chengcheng NiuDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Long WangDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modulation of hypoxia is an essential factor for enhancing the effects of antitumor therapies, especially sonodynamic therapy and chemotherapy. To improve the efficacy of combination therapy by reversing the hypoxic tumor microenvironment, we developed shell-core structured PPID-NPs, which were designed with a polymer shell onto the sonosensitizer and a chemotherapeutic drug were loaded and a perfluorocarbon core loaded with oxygen. The perfluorocarbon core provides sufficient oxygen not only for causing the sonosensitizer to produce more singlet oxygen to induce cell apoptosis but also for reducing drug resistance to enhance therapeutic efficacy. Furthermore, the release of chemotherapeutic drugs at the tumor site can be controlled. Thus, PPID-NPs can efficiently inhibit the growth of breast cancer by synergistic therapy under ultrasound exposure. We believe that our oxygen-sufficient nanoplatform could be an ideal therapeutic system for hypoxic tumors.

Indexed as

chemo-sonodynamic therapyoxygen sufficient nanoplatformperfluorocarbonreactive oxygen speciestumor hypoxia microenvironment

Identifiers

PMID32411675
PMCPMC7199163

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.