ArticleAsia Pacific allergy2020
Suppressive effect of environmental tobacco smoke on murine Th2 cell-mediated nasal eosinophilic inflammation.
Article in Asia Pacific allergy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Associations between dual use of combustible cigarettes and electronic nicotine delivery systems and allergic rhinitis: An analysis of KNHANES data.The World Allergy Organization journal · 2026Article
- α7 nicotinic acetylcholine receptor agonist attenuates allergen-induced immediate nasal response in murine model of allergic rhinitis.The Journal of veterinary medical science · 2024Article
- Expression and Function of Nicotinic Acetylcholine Receptors in Induced Regulatory T Cells.International journal of molecular sciences · 2022Article
- Nicotine in Inflammatory Diseases: Anti-Inflammatory and Pro-Inflammatory Effects.Frontiers in immunology · 2022Review
- Preface to the Proceedings of the 33rd Workshop on Eosinophils in Allergy and Related Diseases 2019 (WEA 2019).Asia Pacific allergy · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEnvironmental tobacco smoke (ETS) exposure is recognized as a risk factor for the development of various respiratory diseases.
objectiveIn this study, the effect of ETS on allergen-immunized and allergen-specific Th2 cell-transferred murine eosinophilic inflammation models and that of cigarette smoke extract (CSE) and nicotine on allergen-induced Th2 cell proliferation and interleukin (IL)-4 production were investigated.
methodsOvalbumin (OVA)-immunized and OVA-specific Th2 cell-transferred BALB/c mice were exposed to ETS and were challenged with OVA. Then, the number of inflammatory cells in the nasal mucosa and nasal hyperresponsiveness (NHR) were assessed. The effects of CSE and nicotine on the allergen-induced proliferative response of and IL-4 production by Th2 cells were determined
resultsIn OVA-immunized and Th2 cell-transferred mice, allergen-induced NHR and nasal eosinophil infiltration were significantly suppressed by ETS exposure, whereas the accumulation of neutrophils was rather enhanced. Allergen-specific Th2 cell proliferation and IL-4 production were inhibited by coculture with CSE. The same effects were induced by nicotine, though the effect on proliferation was relatively weak.
conclusionRegardless of its harmful effect, ETS suppresses NHR, probably through the inhibition of Th2 cell responses.
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