Evidence map›Paper›PMID 32411498›Full record

ArticleAmerican journal of blood research2020

G protein-coupled receptor 68 increases the number of B lymphocytes.

Xiaofei He, Saran Feng, Caleb Hawkins, Lauren Lawley, Wenxin Fan, Yan Xu, Xiang-Ming Zha, Jing Fang

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of blood research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xiaofei HeDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy Columbia, SC, USA.
Saran FengDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy Columbia, SC, USA.
Caleb HawkinsDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy Columbia, SC, USA.
Lauren LawleyDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy Columbia, SC, USA.
Wenxin FanDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy Columbia, SC, USA.
Yan XuDepartment of Obstetrics and Gynecology, Indiana University School of Medicine Indianapolis, IN, USA.
Xiang-Ming ZhaDepartment of Physiology and Cell Biology, University of South Alabama College of Medicine Mobile, SA, USA.
Jing FangDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy Columbia, SC, USA.
University of South Carolina · USIndiana University – Purdue University Indianapolis · USUniversity of South Alabama · US

Funding

Targeting the p62 signalosome in leukemia.R01CA218076 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FANG, JING · 2017 to 2021
$1.7M
NCI NIH HHS R01 CA218076
6 · The paper itself

Abstract

G protein-coupled receptor 68 (GPR68) is a proton sensor that is activated upon binding to extracellular protons. We have previously found that GPR68 induces a proapoptotic pathway in bone marrow (BM) cells from the patients with myelodysplastic syndromes (MDS) after treated with lenalidomide. However, the function of GPR68 in normal hematopoietic cells remains unclear. With genetic loss of function approach, we found reduced frequency and number of B lymphocytes in the peripheral blood (PB) of whole body Gpr68

Indexed as

GPR68 agonistGPR68 allosteric modulatorG protein-coupled receptorshematologic regenerationhematopoiesisstress hematopoiesis

Identifiers

PMID32411498
PMCPMC7218682
OpenAlexW3027570581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.