ArticleAIDS research and treatment2020
Prediction of CD4 T-Lymphocyte Count Using WHO Clinical Staging among ART-Naïve HIV-Infected Adolescents and Adults in Northern Ethiopia: A Retrospective Study.
Article in AIDS research and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Diagnostic accuracy of the WHO clinical staging system for detection of immunologically defined advanced HIV disease: A systematic review and meta-analysis.HIV medicine · 2026Pooled it
- Prevalence of undernutrition among children on anti-retroviral therapy at comprehensive specialized hospital: a cross-sectional study.Scientific reports · 2026Article
- Standard of care in advanced HIV disease: review of HIV treatment guidelines in sub-Saharan African countries-an extension study of eight countries.AIDS research and therapy · 2025Article
- The use of lateral flow lipoarabinomannan for diagnosis of TB in advanced HIV disease in Abia State, Nigeria.Journal of public health in Africa · 2025Article
- Prevalence of uveitis in syphilis patients in Taiwan.Emerging microbes & infections · 2024Article
- Challenges in the delivery of health services for people living with HIV in Dar es Salaam, Tanzania: a qualitative descriptive study among healthcare providers.Frontiers in health services · 2024Article
- Anaemia and Nutritional Status during HIV and Helminth Coinfection among Adults in South Africa.Nutrients · 2022Article
- Article
- Level of Adherence and Associated Factors Among HIV-Infected Patients on Antiretroviral Therapy in Northern Ethiopia: Retrospective Analysis.Patient preference and adherence · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWHO clinical staging has long been used to assess the immunological status of HIV-infected patients at initiation of antiretroviral therapy and during treatment follow-up. In setups where CD4 count determination is not readily available, WHO clinical staging is a viable option. However, correlation between CD4 count and WHO clinical staging is not known in an Ethiopian setting, and hence, the main aim of this study was to assess predictability of CD4 T-lymphocyte count using WHO clinical staging among ART-naïve HIV-infected adolescents and adults in northern Ethiopia.
methodsA retrospective cross-sectional study was done in the Tigray Region, Ethiopia, from April 2015 to January 2019 from a secondary database of 19525 HIV-infected patients on antiretroviral treatment. Analysis was done using STATA-14.0 to estimate the frequencies, mean, and median of CD4 T-cell count in each WHO stages. Sensitivity, specificity, positive predictive value, negative predictive value, kappa test, and correlations were calculated to show the relationships between WHO stages and CD T-cell count.
resultsThe sensitivity of WHO clinical staging to predict CD4 T-cell counts of <200 cells/
conclusionsThe WHO clinical staging had high sensitivity but low specificity in predicting patients with CD4 count <200 cells/
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