Evidence map›Paper›PMID 32411320›Full record

ArticleOxidative medicine and cellular longevity2020

Sulfiredoxin as a Potential Therapeutic Target for Advanced and Metastatic Prostate Cancer.

Caroline N Barquilha, Nilton J Santos, Caio C D Monção, Isabela C Barbosa, Flávio O Lima, Luis A Justulin, Nelma Pértega-Gomes, Sérgio L Felisbino

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. CRL3Nature communications · 2024
    Article
  4. Article
  5. Article
  6. Prostate Cancer Secretome and Membrane Proteome fromInternational journal of molecular sciences · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Hyperoxidation of Peroxiredoxins and Effects on Physiology ofAntioxidants (Basel, Switzerland) · 2021
    Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Caroline N BarquilhaDepartment of Morphology, Institute of Biosciences, São Paulo State University, Botucatu, 18618689 SP, Brazil.ORCID https://orcid.org/0000-0001-7221-4460
Nilton J SantosDepartment of Morphology, Institute of Biosciences, São Paulo State University, Botucatu, 18618689 SP, Brazil.ORCID https://orcid.org/0000-0002-8549-7436
Caio C D MonçãoDepartment of Morphology, Institute of Biosciences, São Paulo State University, Botucatu, 18618689 SP, Brazil.ORCID https://orcid.org/0000-0003-4820-8604
Isabela C BarbosaDepartment of Morphology, Institute of Biosciences, São Paulo State University, Botucatu, 18618689 SP, Brazil.ORCID https://orcid.org/0000-0002-0662-3490
Flávio O LimaDepartment of Pathology, Botucatu Medical School, São Paulo State University, Botucatu, 18618687 SP, Brazil.
Luis A JustulinDepartment of Morphology, Institute of Biosciences, São Paulo State University, Botucatu, 18618689 SP, Brazil.
Nelma Pértega-GomesDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02215 MA, USA.
Sérgio L FelisbinoDepartment of Morphology, Institute of Biosciences, São Paulo State University, Botucatu, 18618689 SP, Brazil.ORCID https://orcid.org/0000-0002-6870-5192
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade Estadual Paulista (Unesp) · BRHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of prostate cancer (PCa) is increasing, and it is currently the second most frequent cause of death by cancer in men. Despite advancements in cancer therapies, new therapeutic approaches are still needed for treatment-refractory advanced metastatic PCa. Cross-species analysis presents a robust strategy for the discovery of new potential therapeutic targets. This strategy involves the integration of genomic data from genetically engineered mouse models (GEMMs) and human PCa datasets. Considering the role of antioxidant pathways in tumor initiation and progression, we searched oxidative stress-related genes for a potential therapeutic target for PCa. First, we analyzed RNA-sequencing data from

Indexed as

Molecular Targeted TherapyAnimalsCell Line, TumorCell SurvivalDisease ProgressionGene Expression Regulation, NeoplasticHumansMaleMiceNeoplasm GradingNeoplasm InvasivenessNeoplasm MetastasisNeoplasm StagingOxidative StressOxidoreductases Acting on Sulfur Group DonorsPrognosisOxidoreductases Acting on Sulfur Group DonorsRNA, MessengerSRXN1 protein, human

Identifiers

PMID32411320
PMCPMC7201699
OpenAlexW3001807898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.