Evidence map›Paper›PMID 32411130›Full record

ArticleFrontiers in immunology2020

The Ratiometric Transcript Signature MX2/GPR183 Is Consistently Associated With RTS,S-Mediated Protection Against Controlled Human Malaria Infection.

Ying Du, Ethan G Thompson, Julius Muller, Joseph Valvo, Jackie Braun, Smitha Shankar, Robert A van den Berg, Erik Jongert, Drew Dover, Jerald Sadoff and 10 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 4 countries.

Ying DuCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.
Ethan G ThompsonCenter for Infectious Disease Research, Seattle, WA, United States.
Julius MullerThe Jenner Institute, Oxford, United Kingdom.
Joseph ValvoCenter for Infectious Disease Research, Seattle, WA, United States.
Jackie BraunCenter for Infectious Disease Research, Seattle, WA, United States.
Smitha ShankarCenter for Infectious Disease Research, Seattle, WA, United States.
Robert A van den BergGSK Vaccines, Rockville, MD, United States.
Erik JongertGSK Vaccines, Rixensart, Belgium.
Drew DoverCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.
Jerald SadoffJanssen Vaccines and Prevention BV, Leiden, Netherlands.
Jenny HendriksJanssen Vaccines and Prevention BV, Leiden, Netherlands.
Malcolm J GardnerInfectious Diseases, J. Craig Venter Institute, La Jolla, CA, United States.
W Ripley BallouGSK Vaccines, Rockville, MD, United States.
Jason A RegulesWalter Reed Army Institute of Research, Silver Spring, MD, United States.
Robbert van der MostGSK Vaccines, Rixensart, Belgium.
Alan AderemCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.
Christian F OckenhousePATH's Malaria Vaccine Initiative, Washington, DC, United States.
Adrian V HillThe Jenner Institute, Oxford, United Kingdom.
Ulrike Wille-ReecePATH's Malaria Vaccine Initiative, Washington, DC, United States.
Daniel E ZakCenter for Infectious Disease Research, Seattle, WA, United States.
Infectious Disease Research Institute · USCenter for Infectious Disease Research · USGlaxoSmithKline (Belgium) · BEGlaxoSmithKline (United States) · USJanssen (Netherlands) · NLJenner Institute · GBU.S. President's Malaria Initiative · USJ. Craig Venter Institute · USWalter Reed Army Institute of Research · US

Funding

Wellcome Trust
6 · The paper itself

Abstract

The RTS,S/AS01 vaccine provides partial protection against

Indexed as

TranscriptomeVaccinationAntibodies, ProtozoanCohort StudiesHumansImmunogenicity, VaccineInfection ControlMalaria, FalciparumMalaria VaccinesMyxovirus Resistance ProteinsPlasmodium falciparumProtozoan ProteinsReceptors, G-Protein-CoupledRNA-SeqSingle-Cell AnalysisVaccines, SyntheticAntibodies, Protozoancircumsporozoite protein, ProtozoanGPR183 protein, humanMalaria VaccinesMX2 protein, humanMyxovirus Resistance ProteinsProtozoan ProteinsReceptors, G-Protein-CoupledRTS,S-AS01 vaccineVaccines, Syntheticclinical immunologyhuman challengeinterferon responsemalaria vaccinessystems vaccinologyvaccine correlates

Identifiers

PMID32411130
PMCPMC7199517
OpenAlexW3021855507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.