Evidence map›Paper›PMID 32411090›Full record

ReviewFrontiers in endocrinology2020

TTF-1 Positive Primary Small Cell Carcinoma of the Breast: A Case Report and Review of the Literature.

Hinda Boutrid, Mahmoud Kassem, Gary Tozbikian, Evan Morgan, Julia White, Manisha Shah, Jeffrey Vandeusen, Sagar Sardesai, Nicole Williams, Daniel G Stover and 9 more

Open access · goldAbstract readCase ReportsReview
In one paragraph

Review in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Neuroendocrine neoplasms of the breast: a review of literature.Virchows Archiv : an international journal of pathology · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Genetic and immunohistochemical profiling of small cell and large cell neuroendocrine carcinomas of the breast.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022
    Article
  7. Review
  8. Article
  9. Breast cancer with neuroendocrine differentiation: an update based on the latest WHO classification.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Hinda BoutridStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United States.
Mahmoud KassemStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United States.
Gary TozbikianDepartment of Pathology, The Ohio State University, Columbus, OH, United States.
Evan MorganStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United States.
Julia WhiteStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United States.
Manisha ShahStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United States.
Jeffrey VandeusenStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United States.
Sagar SardesaiStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United States.
Nicole WilliamsStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United States.
Daniel G StoverStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United States.
Maryam LustbergStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United States.
Robert WesolowskiStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United States.
Vinay PudavalliDepartment of Neurological Surgery, Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, OH, United States.
Terence M WilliamsDepartment of Radiation Oncology, Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, OH, United States.
Bhavana KondaDivision of Medical Oncology, Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, OH, United States.
Stephanie FortierDivision of Medical Oncology, Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, OH, United States.
David CarboneDivision of Medical Oncology, Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, OH, United States.
Bhuvaneswari RamaswamyStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United States.
Mathew A CherianStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United States.
The Ohio State University Wexner Medical Center · USThe Ohio State University · USNeurological Surgery · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary small cell carcinoma of the breast (SCCB) is a rare tumor subtype comprising <0.1% of all breast carcinomas. Here we present a case of thyroid transcription factor-1 (TTF-1) positive SCCB that recurred within 3 years of diagnosis in the lung and lymph nodes. Given the small number of cases, no clear guidelines exist on the appropriate management of patients with these aggressive tumors. We present a case study and review the current literature to highlight the knowledge gaps and needs of patients with these rare tumors. A 50-year-old premenopausal woman with no family history, presented with a palpable right breast mass. Biopsy was consistent with primary SCCB that was poorly differentiated, positive for synaptophysin and chromogranin and TTF-1 and presence of ductal carcinoma

Indexed as

Breast NeoplasmsCarcinoma, Small CellCombined Modality TherapyDNA-Binding ProteinsFemaleHumansMiddle AgedPrognosisTranscription FactorsDNA-Binding ProteinsTranscription FactorsTTF1 protein, humanbreast cancerneuroendocrine cancerPDL-1small cell cancerTTF-1

Identifiers

PMID32411090
PMCPMC7201766
OpenAlexW3022767639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.