Evidence map›Paper›PMID 32410966›Full record

ArticleFrontiers in behavioral neuroscience2020

Changes in Cortisol but Not in Brain-Derived Neurotrophic Factor Modulate the Association Between Sleep Disturbances and Major Depression.

Giuliana Travassos Pires Santiago, Ana Cecília de Menezes Galvão, Raíssa Nóbrega de Almeida, Sergio Arthuro Mota-Rolim, Fernanda Palhano-Fontes, João Paulo Maia-de-Oliveira, Dráulio Barros de Araújo, Bruno Lobão-Soares, Nicole Leite Galvão-Coelho

Open access · goldAbstract read
In one paragraph

Article in Frontiers in behavioral neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
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  3. The Pathogenesis and Treatment of Insomnia Combined with Depression.International journal of general medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Giuliana Travassos Pires SantiagoLaboratory of Hormonal Measurement, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, Brazil.
Ana Cecília de Menezes GalvãoLaboratory of Hormonal Measurement, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, Brazil.
Raíssa Nóbrega de AlmeidaLaboratory of Hormonal Measurement, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, Brazil.
Sergio Arthuro Mota-RolimBrain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
Fernanda Palhano-FontesBrain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
João Paulo Maia-de-OliveiraOnofre Lopes University Hospital, Federal University of Rio Grande do Norte, Natal, Brazil.
Dráulio Barros de AraújoBrain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
Bruno Lobão-SoaresNational Science and Technology Institute for Translational Medicine (INCT-TM), Natal, Brazil.
Nicole Leite Galvão-CoelhoLaboratory of Hormonal Measurement, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, Brazil.
Universidade Federal do Rio Grande do Norte · BRInstituto Nacional de Ciência e Tecnologia Translacional em Medicina

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleep disturbance is a symptom consistently found in major depression and is associated with a longer course of illness, reduced response to treatment, increased risk of relapse and recurrence. Chronic insomnia has been associated with changes in cortisol and serum brain-derived neurotrophic factor (BDNF) levels, which in turn are also changed in major depression. Here, we evaluated the relationship between sleep quality, salivary cortisol awakening response (CAR), and serum BDNF levels in patients with sleep disturbance and treatment-resistant major depression (

Indexed as

brain-derived neurotrophic factorpittsburgh sleep quality indexsalivary cortisol awakening responsesleep disturbancetreatment-resistant depression

Identifiers

PMID32410966
PMCPMC7199815
OpenAlexW3022463612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.