Evidence map›Paper›PMID 32410951›Full record

ArticleFrontiers in neuroscience2020

Angiotensin II-Type I Receptor Antagonism Does Not Influence the Chemoreceptor Reflex or Hypoxia-Induced Central Sleep Apnea in Men.

Courtney V Brown, Lindsey M Boulet, Tyler D Vermeulen, Scott A Sands, Richard J A Wilson, Najib T Ayas, John S Floras, Glen E Foster

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03335904 (Effect of Angiotensin Receptor Blockers on Periodic Breathing During Sleep in Hypoxia), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03335904 phase4completednot on this map

Effect of Angiotensin Receptor Blockers on Periodic Breathing During Sleep in Hypoxia

TypeinterventionalSponsorUniversity of British ColumbiaRan2018 to 2019Enrolled14ConditionsSleep Disordered Breathing, Hypoxia, Respiration, Sleep DisorderArmsHyperoxic Hypercapnic Ventilatory Response Test, Hypoxic Hypercapnic Ventilatory Response Test, Repeated Hypoxic Apneas, Hypoxic Sleep Study, Losartan
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Courtney V BrownCentre for Heart, Lung, and Vascular Health, School of Health and Exercise Science, University of British Columbia - Okanagan, Kelowna, BC, Canada.
Lindsey M BouletCentre for Heart, Lung, and Vascular Health, School of Health and Exercise Science, University of British Columbia - Okanagan, Kelowna, BC, Canada.
Tyler D VermeulenCentre for Heart, Lung, and Vascular Health, School of Health and Exercise Science, University of British Columbia - Okanagan, Kelowna, BC, Canada.
Scott A SandsDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Richard J A WilsonDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Najib T AyasSleep Disorders Program, University of British Columbia, Vancouver, BC, Canada.
John S FlorasUniversity Health Network and Sinai Health System Division of Cardiology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Glen E FosterCentre for Heart, Lung, and Vascular Health, School of Health and Exercise Science, University of British Columbia - Okanagan, Kelowna, BC, Canada.
University of British Columbia · CABrigham and Women's Hospital · USUniversity Health Network · CAUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Components of the renin-angiotensin system (RAS) situated within the carotid body or central nervous system may promote hypoxia-induced chemoreceptor reflex sensitization or central sleep apnea (CSA). We determined if losartan, an angiotensin-II type-I receptor (AT

Indexed as

angiotensin receptorchemoreceptor reflexhumanhypoxiasleep apnea

Identifiers

PMID32410951
PMCPMC7198907
OpenAlexW3027798237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.