ArticleMediators of inflammation2020
Resistin Is Increased in Periodontal Cells and Tissues:
Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 15 citations in OpenAlex.
- Apelin Counteracts the Effects ofInternational journal of molecular sciences · 2024Article
- Apelin - A New Kid on the Block in Periodontology.Oral health & preventive dentistry · 2024Review
- Obesity and Oral Health: The Link Between Adipokines and Periodontitis.TouchREVIEWS in endocrinology · 2024Review
- Salivary and crevicular fluid proinflammatory cytokines and advanced glycation end products in patients with different glycemic levels undergoing fixed orthodontic treatment.The Angle orthodontist · 2024Article
- Gingival crevicular fluid levels of apelin correlates with clinical periodontal diagnosis.Clinical oral investigations · 2023Article
- Role of Resistin in Various Diseases with Special Emphasis on Periodontal and Periapical Inflammation - A Review.Journal of pharmacy & bioallied sciences · 2023Review
- Association between lipid metabolism and periodontitis in obese patients: a cross-sectional study.BMC endocrine disorders · 2023Article
- Apelin Enhances the Effects ofInternational journal of molecular sciences · 2023Article
- Mitochondrial and Redox Changes in Periodontitis and Type 2 Diabetes Human Blood Mononuclear Cells.Antioxidants (Basel, Switzerland) · 2023Article
- Obesity Modifies the Proteomic Profile of the Periodontal Ligament.International journal of molecular sciences · 2023Article
- Serum Resistin Levels and Related Genetic Variants Are Associated With Bone Mineral Density in Postmenopausal Women.Frontiers in endocrinology · 2022Article
- Pharmacological Therapies for the Management of Inflammatory Bone Resorption in Periodontal Disease: A Review of Preclinical Studies.BioMed research international · 2022Review
- Effects of Obesity on Bone Healing in Rats.International journal of molecular sciences · 2021Article
- Type 1 Diabetic Patients After Simultaneous Pancreas and Kidney Transplantation Have Less Intense Periodontal Inflammation Compared to Kidney Recipients Treated with Insulin.Annals of transplantation · 2021Article
- Osteoclasts May Affect Glucose Uptake-Related Insulin Resistance by Secreting Resistin.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resistin, a proinflammatory adipokine, is elevated in many inflammatory diseases. However, little is known about its performance in periodontitis. The present study is aimed at evaluating resistin expression and synthesis in periodontal cells and tissues under inflammatory/microbial stress in addition to its effects on the periodontium. In vivo, 24 male rats were randomly divided into two groups: control and ligature-induced periodontal disease. After 6 and 12 days, animals were sacrificed to analyze gene expression of adipokines, bone loss, inflammation, and resistin synthesis. In vitro, human periodontal ligament (PDL) fibroblasts were used to evaluate the expression of resistin after inflammatory stimuli. In addition, PDL fibroblasts were exposed to resistin to evaluate its role on soft and hard tissue metabolism markers. The periodontitis group demonstrated significant bone loss, an increase in the number of inflammatory cells and vascular structures, an increase in resistin expression and synthesis, and a decrease in the expression of adiponectin, leptin, and its functional receptor. PDL fibroblasts showed a significant increase in resistin expression and synthesis in response to the inflammatory stimulus by IL-1
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.