Evidence map›Paper›PMID 32410852›Full record

ArticleMediators of inflammation2020

IL-4 Receptor-Alpha Signalling of Intestinal Epithelial Cells, Smooth Muscle Cells, and Macrophages Plays a Redundant Role in Oxazolone Colitis.

Jennifer Claire Hoving, Roanne Keeton, Maxine A Höft, Mumin Ozturk, Patricia Otieno-Odhiambo, Frank Brombacher

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jennifer Claire HovingAFGrica Medical Mycology Research Unit, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa, MRC Centre for Medical Mycology at the University of Exeter, Geoffrey Pope Building Stocker Road, Exeter, UK.ORCID https://orcid.org/0000-0002-7162-5855
Roanne KeetonInstitute of Infectious Diseases and Molecular Medicine (IDM), Department of Pathology, Faculty of Health Sciences, University of Cape Town, South Africa.
Maxine A HöftAFGrica Medical Mycology Research Unit, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa, MRC Centre for Medical Mycology at the University of Exeter, Geoffrey Pope Building Stocker Road, Exeter, UK.ORCID https://orcid.org/0000-0002-5719-9458
Mumin OzturkInstitute of Infectious Diseases and Molecular Medicine (IDM), Department of Pathology, Faculty of Health Sciences, University of Cape Town, South Africa.ORCID https://orcid.org/0000-0001-9152-7614
Patricia Otieno-OdhiamboAFGrica Medical Mycology Research Unit, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa, MRC Centre for Medical Mycology at the University of Exeter, Geoffrey Pope Building Stocker Road, Exeter, UK.
Frank BrombacherInstitute of Infectious Diseases and Molecular Medicine (IDM), Department of Pathology, Faculty of Health Sciences, University of Cape Town, South Africa.ORCID https://orcid.org/0000-0001-8881-6781
University of Cape Town · ZASouth African Medical Research Council · ZA

Funding

Wellcome Trust 209293/Z/17/Z
6 · The paper itself

Abstract

A hallmark of ulcerative colitis is the chronic colonic inflammation, which is the result of a dysregulated intestinal mucosal immune response. Epithelial barrier disruption which allows the entry of microorganisms eventually leads to more aggressive inflammation and potentially the removal of the colon. We have previously shown that the T helper- (Th-) type 2 cytokines, Interleukin- (IL-) 4 and IL-13, mediate CD4+ T cell- or B cell-driven inflammation in the oxazolone-induced mouse model of ulcerative colitis. In contrast, mice deficient in the shared receptor of IL-4 and IL-13, IL-4 receptor-alpha (IL-4R

Indexed as

AnimalsCD4-Positive T-LymphocytesColitisColonEpithelial CellsGene DeletionInflammationInterleukin-13Interleukin-4 Receptor alpha SubunitMacrophagesMaleMiceMice, Inbred BALB CMyocytes, Smooth MuscleOxazoloneReceptors, Cell SurfaceIl4ra protein, mouseInterleukin-13Interleukin-4 Receptor alpha SubunitOxazoloneReceptors, Cell Surface

Identifiers

PMID32410852
PMCPMC7201672
OpenAlexW2999466319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.