Evidence map›Paper›PMID 32410845›Full record

ArticleMediators of inflammation2020

IL-33 Inhibits Hepatitis B Virus through Its Receptor ST2 in Hydrodynamic HBV Mouse Model.

Xiuzhu Gao, Xiumei Chi, Xiaomei Wang, Ruihong Wu, Hongqin Xu, MengRu Zhan, Dong Li, Yanhua Ding, Damo Xu, Junqi Niu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xiuzhu GaoDepartment of Hepatology, The First Hospital of Jilin University, Jilin University, 71 XinMin Street, Changchun, Jilin Province 130021, China.ORCID https://orcid.org/0000-0001-6310-1456
Xiumei ChiDepartment of Hepatology, The First Hospital of Jilin University, Jilin University, 71 XinMin Street, Changchun, Jilin Province 130021, China.ORCID https://orcid.org/0000-0002-6291-8496
Xiaomei WangDepartment of Hepatology, The First Hospital of Jilin University, Jilin University, 71 XinMin Street, Changchun, Jilin Province 130021, China.ORCID https://orcid.org/0000-0003-2606-4013
Ruihong WuDepartment of Hepatology, The First Hospital of Jilin University, Jilin University, 71 XinMin Street, Changchun, Jilin Province 130021, China.ORCID https://orcid.org/0000-0001-7585-0059
Hongqin XuDepartment of Hepatology, The First Hospital of Jilin University, Jilin University, 71 XinMin Street, Changchun, Jilin Province 130021, China.ORCID https://orcid.org/0000-0002-7022-7732
MengRu ZhanDepartment of Hepatology, The First Hospital of Jilin University, Jilin University, 71 XinMin Street, Changchun, Jilin Province 130021, China.ORCID https://orcid.org/0000-0002-2419-6859
Dong LiDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.ORCID https://orcid.org/0000-0002-2508-3282
Yanhua DingPhase I Clinical Research Center, The First Hospital of Jilin University, Jilin University, 71 XinMin Street, Changchun, Jilin Province 130021, China.ORCID https://orcid.org/0000-0002-0498-8939
Damo XuMedical School, Shenzhen University, Shenzhen 518052, China.ORCID https://orcid.org/0000-0001-9787-2099
Junqi NiuDepartment of Hepatology, The First Hospital of Jilin University, Jilin University, 71 XinMin Street, Changchun, Jilin Province 130021, China.ORCID https://orcid.org/0000-0002-5187-7297
Jilin University · CNShenzhen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin-33 has been demonstrated to be associated with liver damage. However, its potential value in hepatitis B virus (HBV) infection remains unknown. This study was designed to investigate the role of IL-33 in hydrodynamic HBV mouse model. Different doses of IL-33 were used to treat HBV wild-type, ST2 knockout, CD8+ T depletion, NK depletion C57BL/6 mice and C.B-17 SCID and nod SCID mouse, respectively. The concentrations of HBV DNA, HBsAg, HBeAg, and molecules related to liver function were detected in the collected serum at different time points from model mice. Intrahepatic HBcAg was visualized by immunohistochemical staining of liver tissues.

Indexed as

Hepatitis B virusAnimalsCD8-Positive T-LymphocytesHEK293 CellsHepatitis BHumansHydrodynamicsInterleukin-1 Receptor-Like 1 ProteinInterleukin-33Killer Cells, NaturalMiceMice, Inbred C57BLMice, SCIDIL1RL1 protein, humanIl1rl1 protein, mouseIL33 protein, humanIl33 protein, mouseInterleukin-1 Receptor-Like 1 ProteinInterleukin-33

Identifiers

PMID32410845
PMCPMC7204199
OpenAlexW3022323339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.