ArticleChemistry of materials : a publication of the American Chemical Society2019
Rapid Diels-Alder Cross-linking of Cell Encapsulating Hydrogels.
Article in Chemistry of materials : a publication of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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Who cites it
39 citing papers in PubMed.
- ROPISA Synthetic Strategy for Photo-Crosslinked Aqueous Polypeptide Nano-Assemblies.Chemistry, an Asian journal · 2026Article
- Stress relaxation timescale and hydrogel network connectivity regulate neural progenitor cell stemness and differentiation.Journal of materials chemistry. B · 2026Article
- Click Chemistry-Based Hydrogels for Tissue Engineering.Gels (Basel, Switzerland) · 2025Review
- Dual-Dynamic Covalently Cross-Linked Polyglycerol Hydrogels for Tumor Spheroid Culture.Biomacromolecules · 2025Article
- Diverse reactivity of maleimides in polymer science and beyond.Polymer international · 2025Article
- Focused Ultrasound-Mediated Release of Bone Morphogenetic Protein 2 from Hydrogels for Bone Regeneration.Gels (Basel, Switzerland) · 2025Article
- Applications of Diels-Alder Chemistry in Biomaterials and Drug Delivery.Macromolecular bioscience · 2024Review
- Cell-Material Interactions in Covalent Adaptable Thioester Hydrogels.ACS biomaterials science & engineering · 2024Article
- Metal-Free Click-Chemistry: A Powerful Tool for Fabricating Hydrogels for Biomedical Applications.Bioconjugate chemistry · 2024Review
- 3D bioprinting of microorganisms: principles and applications.Bioprocess and biosystems engineering · 2024Review
- Custom-engineered hydrogels for delivery of human iPSC-derived neurons into the injured cervical spinal cord.Biomaterials · 2024Article
- Spatial-Selective Volumetric 4D Printing and Single-Photon Grafting of Biomolecules within Centimeter-Scale Hydrogels via Tomographic Manufacturing.Advanced materials technologies · 2023Article
- Advances in Gelatin Bioinks to Optimize Bioprinted Cell Functions.Advanced healthcare materials · 2023Review
- Protein-Based Hydrogels and Their Biomedical Applications.Molecules (Basel, Switzerland) · 2023Review
- Click and bioorthogonal hyaluronic acid hydrogels as an ultra-tunable platform for the investigation of cell-material interactions.Bioactive materials · 2023Article
- Recent progress of antibacterial hydrogels in wound dressings.Materials today. Bio · 2023Review
- Alginate-Gelatin Self-Healing Hydrogel Produced via Static-Dynamic Crosslinking.Molecules (Basel, Switzerland) · 2023Article
- Self-Forming Norbornene-Tetrazine Hydrogels with Independently Tunable Properties.Macromolecular bioscience · 2023Article
- Engineering Hydrogels for Modulation of Dendritic Cell Function.Gels (Basel, Switzerland) · 2023Review
- Recent Advances in Hydrogels via Diels-Alder Crosslinking: Design and Applications.Gels (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Recent efforts in the design of hydrogel biomaterials have focused on better mimicking the native cellular microenvironment to direct cell fate. To simultaneously control multiple material parameters, several orthogonal chemistries may be needed. However, present strategies to prepare cell-encapsulating hydrogels make use of relatively few chemical reactions. To expand this chemical toolkit, we report the preparation of hydrogels based on a Diels-Alder reaction between fulvenes and maleimides with markedly improved gelation kinetics and hydrolytic stability. Fulvene-maleimide gels cross-link up to 10-times faster than other commonly used DA reaction pairs and remain stable for months under physiological conditions. Furthermore, fulvene-maleimide gels presenting relevant biochemical cues, such as cell-adhesive ligands and proteolytic degradability, support the culture of human mesenchymal stromal cells. Finally, this rapid DA reaction was combined with an orthogonal click reaction to demonstrate how the use of selective chemistries can provide new avenues to incorporate multiple functionalities in hydrogel materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.