ArticleActa histochemica et cytochemica2020
Investigation of Novel c-Kit-expressing Smooth Muscle Cells in Murine Cecum.
Article in Acta histochemica et cytochemica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Hedgehog pathway disruption alters urothelial differentiation and continence mechanisms in the female mouse lower urinary tract.American journal of physiology. Renal physiology · 2026Article
- Molecular imaging of gastrointestinal stromal tumor using anti-c-KIT antibody and its fragments.Journal of gastroenterology · 2025Article
- Dietary fiber from burdock root ameliorates functional constipation in aging rats by regulating intestinal motility.Frontiers in nutrition · 2025Article
- Interstitial cells of Cajal in WJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the gastrointestinal tract musculatures, c-Kit receptor tyrosine kinase is specifically expressed in interstitial cells of Cajal (ICC). ICC are distributed among the smooth muscle cells and are either bipolar or multipolar in shape. Our previous and current study shows that c-Kit-immunopositive smooth muscle cells are present in the murine cecum. Here, we found that c-Kit-expressing smooth muscle cells (named Kit-SM cells) are situated at the submucosal surface of the circular muscle layer. These cells showed smooth muscle actin and myosin immunoreactivities and ultrastructural features such as thick and thin filaments and caveolae. Kit-SM cells also expressed TMEM16A and LRIG1, which are known to be expressed in ICC. Although the functional significance of Kit-SM cells has yet to be revealed, these cells can be considered to have proliferation or differentiation potential in the cecal musculature.
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