Evidence map›Paper›PMID 32410669›Full record

ArticleActa neuropathologica communications2020

Epigenomics and transcriptomics analyses of multiple system atrophy brain tissue supports a role for inflammatory processes in disease pathogenesis.

Conceição Bettencourt, Ignazio S Piras, Sandrine C Foti, Joshua Talboom, Yasuo Miki, Tammaryn Lashley, Robert Balazs, Emmanuelle Viré, Thomas T Warner, Matt J Huentelman and 1 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Inflammation in multiple system atrophy.Frontiers in immunology · 2023
    Review
  3. Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society · 2022
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Conceição BettencourtQueen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK. c.bettencourt@ucl.ac.uk.ORCID 0000-0001-9090-7690
Ignazio S PirasNeurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
Sandrine C FotiQueen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Joshua TalboomNeurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
Yasuo MikiQueen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Tammaryn LashleyQueen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Robert BalazsQueen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Emmanuelle ViréInstitute of Prion Diseases, MRC Prion Unit at UCL, Courtauld Building, 33 Cleveland Street, London, UK.
Thomas T WarnerQueen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Matt J HuentelmanNeurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
Janice L HoltonQueen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.

Funding

Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5M
National Brain and Tissue Resource for Parkinson's Disease and Related DisordersU24NS072026 · NINDS · BANNER SUN HEALTH RESEARCH INSTITUTE · PI BEACH, THOMAS G · 2011 to 2015
$7.8M
Identification of pathogenic mechanisms important in multiple system atrophyR21NS093222 · NINDS · TRANSLATIONAL GENOMICS RESEARCH INST · PI HUENTELMAN, MATT · 2015 to 2016
$543k
Medical Research Council MR/L023784/1Medical Research Council MR/L023784/2NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG19610NINDS NIH HHS R21 NS093222NINDS NIH HHS R21-NS093222NINDS NIH HHS U24 NS072026
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BrainEncephalitisEpigenomicsGene Expression ProfilingHumansMultiple System AtrophyDNA methylationEWASGene expressionInflammationMethylomicsMSANeurodegenerationRNAseqTranscriptomics

Identifiers

PMID32410669
PMCPMC7227350

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.