ArticleBMC plant biology2020
Genome-wide identification and functional characterization of cotton (Gossypium hirsutum) MAPKKK gene family in response to drought stress.
Article in BMC plant biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Genome-Wide Identification and Expression Analysis of Kinase Proteins in Land Plants and Their Expression in Gossypium hirsutum Under Salt Stress.Molecular biotechnology · 2026Article
- Fungal MicroRNA-Like RNAs Facilitate Convergent Attack on a Host Immune Signalling Network.Plant, cell & environment · 2026Article
- Identification of salt-responsive mitogen-activated protein kinase cascade members in the halophyte N. sibirica.BMC plant biology · 2026Article
- Harnessing Plant Microbiomes to Modulate Molecular Signaling and Regulatory Networks in Drought Stress Adaptation.International journal of molecular sciences · 2026Review
- Integrated Analysis of Physiological Responses and Transcriptome of Cotton Seedlings Under Drought Stress.International journal of molecular sciences · 2025Article
- Genome-wide identification and unveiling the role of MAP kinase cascade genes involved in sugarcane response to abiotic stressors.BMC plant biology · 2025Article
- Drought Tolerance in Plants: Physiological and Molecular Responses.Plants (Basel, Switzerland) · 2024Review
- Decoding drought resilience: a comprehensive exploration of the cotton Eceriferum (CER) gene family and its role in stress adaptation.BMC plant biology · 2024Article
- Article
- Genomic insights into CKX genes: key players in cotton fibre development and abiotic stress responses.PeerJ · 2024Article
- Comparative transcriptome profiling to unravel the key molecular signalling pathways and drought adaptive plasticity in shoot borne root system of sugarcane.Scientific reports · 2023Article
- Genome-Wide Characterization and Functional Analysis of ABCG Subfamily Reveal Its Role in Cutin Formation in Cotton.International journal of molecular sciences · 2023Article
- Systematic analysis of Histidine photosphoto transfer gene family in cotton and functional characterization in response to salt and around tolerance.BMC plant biology · 2022Article
- Protein S-Acyl Transferase GhPAT27 Was Associated withPlants (Basel, Switzerland) · 2022Article
- A Comprehensive Gene Co-Expression Network Analysis Reveals a Role ofInternational journal of molecular sciences · 2022Article
- Genome-Wide Identification and Expression Analysis of MAPK Gene Family in Lettuce (International journal of molecular sciences · 2022Article
- Role of WRKY Transcription Factors in Regulation of Abiotic Stress Responses in Cotton.Life (Basel, Switzerland) · 2022Review
- Structure and character analysis of cotton response regulator genes family reveals that GhRR7 responses to draught stress.Biological research · 2022Article
- Mitogen-Activated Protein Kinase and Substrate Identification in Plant Growth and Development.International journal of molecular sciences · 2022Review
- Genome-wide identification, evolutionary estimation and functional characterization of two cotton CKI gene types.BMC plant biology · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMitogen-activated protein kinase kinase kinases (MAPKKKs) are significant components in the MAPK signal pathway and play essential roles in regulating plants against drought stress. To explore MAPKKK gene family functioning in cotton response and resistance to drought stress, we conducted a systematic analysis of GhMAPKKKs.
resultsIn this study, 157 nonredundant GhMAPKKKs (including 87 RAFs, 46 MEKKs and 24 ZIKs) were identified in cotton (Gossypium hirsutum). These GhMAPKKK genes are unevenly distributed on 26 chromosomes, and segmental duplication is the major way for the enlargement of MAPKKK family. Furthermore, members within the same subfamily share a similar gene structure and motif composition. A lot of cis-elements relevant to plant growth and response to stresses are distributed in promoter regions of GhMAPKKKs. Additionally, these GhMAPKKKs show differential expression patterns in cotton tissues. The transcription levels of most genes were markedly altered in cotton under heat, cold and PEG treatments, while the expressions of some GhMAPKKKs were induced in cotton under drought stress. Among these drought-induced genes, we selected GhRAF4 and GhMEKK12 for further functional characterization by virus-induced gene silencing (VIGS) method. The experimental results indicated that the gene-silenced cotton displayed decreased tolerance to drought stress. Malondialdehyde (MDA) content was higher, but proline accumulation, relative leaf water content and activities of superoxide dismutase (SOD) and peroxidase (POD) were lower in the gene-silenced cotton, compared with those in the controls, under drought stress.
conclusionCollectively, a systematic survey of gene structure, chromosomal location, motif composition and evolutionary relationship of MAPKKKs were performed in upland cotton (Gossypium hirsutum). The following expression and functional study showed that some of them take important parts in cotton drought tolerance. Thus, the data presented here may provide a foundation for further investigating the roles of GhMAPKKKs in cotton response and resistance to drought stress.
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